Quantitative residual cortical activity measurement: Appropriate test for diagnosis of renal artery stenosis?

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dc.contributor.authorGezici, A
dc.contributor.authorErsay, A
dc.contributor.authorAntevska, E
dc.contributor.authorHeidental, GK
dc.contributor.authorSchreij, G
dc.contributor.authorDemirtas, OC
dc.date.accessioned2024-04-24T17:12:19Z
dc.date.available2024-04-24T17:12:19Z
dc.date.issued1999
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To evaluate the diagnostic validity of quantitative measurement of residual cortical activity (RCA) in renal artery stenosis (RAS). Methods: In 45 patients with a high clinical likelihood of renovascular hypertension (RVH) and unimpaired renal function, dynamic imaging was performed after an intravenous bolus injection of 148 MBq Tc-99m MAG3 for both baseline renoscintigraphy and captopril renography following oral application of 50 mg captopril. RCA was measured according to the Sfa-kianakis method: RCA = cortical counts at 20 min/counts at peak x 100%. An increase in RCA of greater than or equal to 5% from baseline was considered indicative of RAS. After renography, all patients underwent selective transfemoral angiography with the digital subtraction technique. A luminal reduction of greater than or equal to 50% was considered as proof of RAS. Results: The number of kidneys that had a change of 15% in RCA values was 12 (27.2%) in normal kidneys, 7 (58.3%) in the patients with bilateral RAS, 14(82.3%) in the patients with unilateral RAS, and 21 (72.4%) in overall kidneys with RAS. The positive test ratio in pathologic groups was significantly higher than normal (p < 0.05). The sensitivity and specificity of the RCA test were 72.4 and 72.7%, respectively; the positive and negative predictive values were 63.6 and 80%, respectively. Conclusion: Quantitative measurements of RCA can be used as a diagnostic parameter of renal artery stenosis and may contribute of the diagnostic accuracy of visual interpretation and other renographic diagnostic criteria.en_US
dc.identifier.doi10.1159/000030345
dc.identifier.endpage7en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue1en_US
dc.identifier.pmid10436422
dc.identifier.scopus2-s2.0-0032772663
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1159/000030345
dc.identifier.urihttps://hdl.handle.net/11468/17931
dc.identifier.volume62en_US
dc.identifier.wosWOS:000081915200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaptopril Renographyen_US
dc.subjectResidual Cortical Activityen_US
dc.subjectRenal Artery Stenosisen_US
dc.titleQuantitative residual cortical activity measurement: Appropriate test for diagnosis of renal artery stenosis?en_US
dc.titleQuantitative residual cortical activity measurement: Appropriate test for diagnosis of renal artery stenosis?
dc.typeArticleen_US

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