Quantitative residual cortical activity measurement: Appropriate test for diagnosis of renal artery stenosis?
[ X ]
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To evaluate the diagnostic validity of quantitative measurement of residual cortical activity (RCA) in renal artery stenosis (RAS). Methods: In 45 patients with a high clinical likelihood of renovascular hypertension (RVH) and unimpaired renal function, dynamic imaging was performed after an intravenous bolus injection of 148 MBq Tc-99m MAG3 for both baseline renoscintigraphy and captopril renography following oral application of 50 mg captopril. RCA was measured according to the Sfa-kianakis method: RCA = cortical counts at 20 min/counts at peak x 100%. An increase in RCA of greater than or equal to 5% from baseline was considered indicative of RAS. After renography, all patients underwent selective transfemoral angiography with the digital subtraction technique. A luminal reduction of greater than or equal to 50% was considered as proof of RAS. Results: The number of kidneys that had a change of 15% in RCA values was 12 (27.2%) in normal kidneys, 7 (58.3%) in the patients with bilateral RAS, 14(82.3%) in the patients with unilateral RAS, and 21 (72.4%) in overall kidneys with RAS. The positive test ratio in pathologic groups was significantly higher than normal (p < 0.05). The sensitivity and specificity of the RCA test were 72.4 and 72.7%, respectively; the positive and negative predictive values were 63.6 and 80%, respectively. Conclusion: Quantitative measurements of RCA can be used as a diagnostic parameter of renal artery stenosis and may contribute of the diagnostic accuracy of visual interpretation and other renographic diagnostic criteria.
Açıklama
Anahtar Kelimeler
Captopril Renography, Residual Cortical Activity, Renal Artery Stenosis
Kaynak
Urologia Internationalis
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
62
Sayı
1
