Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorLaçin, Nihat
dc.contributor.authorDeveci, Engin
dc.date.accessioned2021-09-30T06:43:41Z
dc.date.available2021-09-30T06:43:41Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionPMID:31531539
dc.description.abstractPurpose: The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats. Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group. Results: Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions. Conclusion: Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment.en_US
dc.identifier.citationLaçin, N. ve Deveci, E. (2019). Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats. Acta Cirurgica Brasileira, 34(7), e201900704.en_US
dc.identifier.doi10.1590/s0102-865020190070000004
dc.identifier.issn0102-8650
dc.identifier.issue7en_US
dc.identifier.pmid31531539
dc.identifier.scopus2-s2.0-85072291956
dc.identifier.scopusqualityQ2
dc.identifier.startpagee201900704en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/tnR3hZdyxpmzXZ4MX6wJz9v/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/7832
dc.identifier.volume34en_US
dc.identifier.wosWOS:000485792900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectRatsen_US
dc.subjectResveratrolen_US
dc.subjectSkullen_US
dc.titleShort-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in ratsen_US
dc.titleShort-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
dc.typeArticleen_US

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