Immunoexpression of vascular endothelial growth factor and B-cell lymphoma 2 in the uterine tissue of rats treated with melatonin in the estrus phase

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorGörük, Neval Yaman
dc.contributor.authorDeveci, Engin
dc.date.accessioned2022-12-09T08:09:18Z
dc.date.available2022-12-09T08:09:18Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionPMID: 30110064
dc.description.abstractPurpose: To investigate the effect of melatonin on uterine tissue in the ovariectomized rat model. Methods: Fourty Wistar albino rats were divided into four groups for histologic and immunohistochemical examination. The rats were first numbered randomly and then randomly divided into 4 equal groups: control (group 1), torsion (group 2), torsion+detorsion (group 3) and torsion+detorsion+melatonin (group 4) groups. In addition, four Wistar albino rats were used for western blot analysis in each group. And also, malondialdehyde (MDA) levels were measured biochemically in all rats. Results: The histopathological examination of the uterine tissue in rats ovarectomized showed a degeneration in uterine glands, dilation of blood vessels in the internal layer with a thrombosis and bleeding, abnormal nucleuses and vacuolated cytoplasm above and below the nucleus. In torsion group, the apoptotic cells increased in luminal epithelium and gland cells. In the melatonin group showed that the Bcl2 negative effect on the uterine epithelium and did not lead to apoptotic cells. Conclusion: The increase in vascular endothelial growth factor expression resulted in the rearrangement of endothelial cell growth and the induction of angiogenesis.en_US
dc.identifier.citationGörük, N. Y. ve Deveci, E. (2018). Immunoexpression of vascular endothelial growth factor and B-cell lymphoma 2 in the uterine tissue of rats treated with melatonin in the estrus phase. Acta Cirurgica Brasileira, 33(7), 629-640.en_US
dc.identifier.doi10.1590/s0102-865020180070000008
dc.identifier.endpage640en_US
dc.identifier.issn0102-8650
dc.identifier.issue7en_US
dc.identifier.pmid30110064
dc.identifier.scopus2-s2.0-85051733958
dc.identifier.scopusqualityQ2
dc.identifier.startpage629en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/ZyhRmHx3czxhc8GyTMR5WmP/
dc.identifier.urihttps://hdl.handle.net/11468/10993
dc.identifier.volume33en_US
dc.identifier.wosWOS:000441179000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectB-Cellen_US
dc.subjectLymphomaen_US
dc.subjectMelatoninen_US
dc.subjectOvaryen_US
dc.subjectUterusen_US
dc.subjectVascular endothelial growth factor A ratsen_US
dc.titleImmunoexpression of vascular endothelial growth factor and B-cell lymphoma 2 in the uterine tissue of rats treated with melatonin in the estrus phaseen_US
dc.titleImmunoexpression of vascular endothelial growth factor and B-cell lymphoma 2 in the uterine tissue of rats treated with melatonin in the estrus phase
dc.typeArticleen_US

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