Low serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational study

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dc.contributor.authorErtas, Faruk
dc.contributor.authorKaya, Hasan
dc.contributor.authorSoydinc, Mehmet Serdar
dc.date.accessioned2024-04-24T17:25:01Z
dc.date.available2024-04-24T17:25:01Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate the relationship between serum thyroid hormone levels that are within the normal range and the presence and severity of coronary artery disease (CAD) in patients referred for coronary angiography. Methods: In this observational study, we enrolled 119 consecutive patients (77 men, mean age 60.7 +/- 13.8 years) who underwent coronary angiography. Blood samples were tested for thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) concentrations. Additionally, risk factors, clinical characteristics and angiographic results were obtained. The patients were separated into two groups according to the Gensini score as those with mild or severe atherosclerosis. Statistical analysis was performed using the Chi-square, Mann-Whitney U, correlation and logistic regression tests, and ROC analysis. Results: FT3 levels were significantly lower in subjects with CAD (4.0 +/- 0.7 vs. 4.6 +/- 0.6 pmol/L; p<0.001). Moreover, lower FT3 levels were found in patients with severe atherosclerosis (3.9 +/- 0.7 vs. 4.5 +/- 0.6 pmol/L; p<0.001). Logistic regression analysis demonstrated that the lower FT3 levels were associated with the presence (OR =0.266, 95% CI: 0.097-0.731, p=0.01) and severity (OR=0.238, 95% CI: 0.083-0.685, p=0.008) of CAD. In the ROC analysis, a level of FT3 <= 4.2 pmol/L was found to predict the presence of CAD with 69% sensitivity and 71% specificity (AUC: 0.744, 95% CI: 0.653-0.834, p<0.001); and the severity of CAD with 75% sensitivity and 67% specificity (AUC: 0.733, 95% CI: 0.642-0.824, p<0.001). Conclusions: FT3 levels within the normal range were inversely correlated with the presence and severity of CAD. Moreover, lower FT3 concentrations were correlated with the Gensini score and independently predicted the presence and severity of CAD. Thus, the FT3 levels may be used as the indicator of increased risk for CAD. (Anadolu Kardiyol Derg 2012; 12: 591-6)en_US
dc.identifier.doi10.5152/akd.2012.187
dc.identifier.endpage596en_US
dc.identifier.issn1302-8723
dc.identifier.issue7en_US
dc.identifier.pmid22877896en_US
dc.identifier.scopus2-s2.0-84868283885en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage591en_US
dc.identifier.trdizinid145247en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2012.187
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/145247
dc.identifier.urihttps://hdl.handle.net/11468/19912
dc.identifier.volume12en_US
dc.identifier.wosWOS:000312740700018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAves Yayinciliken_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectGensini Scoreen_US
dc.subjectThyroid Hormone Levelsen_US
dc.subjectRegression Analysisen_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.titleLow serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational studyen_US
dc.typeArticleen_US

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