Chemical Compositions by Using LC-MS/MS and GC-MS and Biological Activities of Sedum sediforme (Jacq.) Pau

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dc.contributor.authorErtas, Abdulselam
dc.contributor.authorBoga, Mehmet
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorYesil, Yeter
dc.contributor.authorHasimi, Nesrin
dc.contributor.authorKaya, Meryem Seyda
dc.contributor.authorTemel, Hamdi
dc.date.accessioned2024-04-24T16:19:07Z
dc.date.available2024-04-24T16:19:07Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this research, the chemical composition and biological activities of various extracts obtained from whole parts of Sedum sediforme (Jacq.) Pau were compared. The amounts of total phenolic and flavonoid components in crude extracts were determined by expression as pyrocatechol and quercetin equivalents, respectively. All of the extracts (petroleum ether, acetone, methanol, and water) obtained from S. sediforme showed strong antioxidant activity in four tested methods. Particularly, the IC50 values of the methanol extract, which was the richest in terms of total phenolic and flavonoid contents, were found to be lower than those of alpha-tocopherol and BHT in beta-carotene bleaching (9.78 +/- 0.06 mu g/mL), DPPH free radical scavenging (9.07 +/- 0.07 mu g/mL), and ABTS cation radical scavenging (5.87 +/- 0.03 mu g/mL) methods. Furthermore, the methanol extract of S. sediforme showed higher inhibition activity than galanthamine against acetyl- and butyryl-cholinesterase enzymes. Also, acetone and methanol extracts exhibited moderate antimicrobial activity against Candida albicans. The main constituents of fatty acid and essential oil were identified as palmitic acid (C16:0) (28.8%) and alpha-selinene (20.4%), respectively, by GC-MS. In the methanol extract of S. sediforme, quercetin, rutin, naringenin, and protocatechuic, p-coumaric, caffeic, and chlorogenic acids were detected and quantified by LC-MS/MS. Results of the current study showed that the methanol extract of S. sediforme may also be used as a food supplement.en_US
dc.description.sponsorshipDicle University [DUBAP: 13-ASMYO-61]; Dicle University Science and Technology Research and Application Center (DUBTAM)en_US
dc.description.sponsorshipWe acknowledge the Dicle University for financial support (Research University Grant DUBAP: 13-ASMYO-61). We thank Dicle University Science and Technology Research and Application Center (DUBTAM) for the partial support of this study.en_US
dc.identifier.doi10.1021/jf500067q
dc.identifier.endpage4609en_US
dc.identifier.issn0021-8561
dc.identifier.issn1520-5118
dc.identifier.issue20en_US
dc.identifier.pmid24773044
dc.identifier.scopus2-s2.0-84901262022
dc.identifier.scopusqualityQ1
dc.identifier.startpage4601en_US
dc.identifier.urihttps://doi.org/10.1021/jf500067q
dc.identifier.urihttps://hdl.handle.net/11468/16403
dc.identifier.volume62en_US
dc.identifier.wosWOS:000336417200015
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSedum Sediformeen_US
dc.subjectPhenolic Contenten_US
dc.subjectEssential Oilen_US
dc.subjectFatty Aciden_US
dc.subjectAntioxidanten_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntimicrobialen_US
dc.subjectQuercetinen_US
dc.subjectLc-Ms/Msen_US
dc.subjectGc-Msen_US
dc.titleChemical Compositions by Using LC-MS/MS and GC-MS and Biological Activities of Sedum sediforme (Jacq.) Pauen_US
dc.titleChemical Compositions by Using LC-MS/MS and GC-MS and Biological Activities of Sedum sediforme (Jacq.) Pau
dc.typeArticleen_US

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