The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus

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dc.authorid0000-0003-3158-3678en_US
dc.authorid0000-0002-9017-763Xen_US
dc.contributor.authorAltan, Semih
dc.contributor.authorDönmez, Kaan
dc.contributor.authorAltan, Feray
dc.contributor.authorAlkan, Fahrettin
dc.date.accessioned2023-10-30T06:47:00Z
dc.date.available2023-10-30T06:47:00Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü, Cerrahi Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study was to evaluate the effects of the three different prokinetic agents, namely erythromycin, lidocaine, and metoclopramide in lambs with postoperative ileus (POI) using motilin and ghrelin, which are known as motility markers. Twenty lambs were allocated to 4 groups of 5 lambs each. An enterotomy was performed on the ileum of each lamb. Erythromycin (8.8 mg/ kg), metoclopramide (0.2 mg/kg), and saline (2 mL) were administered as single dose IM before surgery in the ERT, MET, and CNTR groups, respectively. Lidocaine was administered to the LID group, both as a bolus before (1.3 mg/kg IV) and as a continuous rate infusion during surgery (0.05 mg/kg/h IV). Serum motilin and ghrelin concentrations as motility hormones were measured with ELISA. The serum motilin concentration was significantly higher at 0, 1, 3, 5, 10, 24, and 48 h in the ERT group and at 1 and 10 h in the LID group. The serum ghrelin concentration was significantly higher at 0, 1, and 48 h in the ERT group and at 3, 5, 10, 24, and 48 h in the LID group. As a result, erythromycin and lidocaine was thought to be useful in lambs with POI according to the stimulatory effects on the motility hormones.en_US
dc.description.sponsorshipDicle University Veteriner.15.002en_US
dc.identifier.citationAltan, S., Dönmez, K., Altan, F. ve Alkan, F. (2018). The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus. Turkish Journal of Veterinary and Animal Sciences, 42(5), 435-440.en_US
dc.identifier.doi10.3906/vet-1803-3
dc.identifier.endpage440en_US
dc.identifier.issn1300-0128
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85055889998
dc.identifier.scopusqualityQ3
dc.identifier.startpage435en_US
dc.identifier.trdizinid356863
dc.identifier.urihttps://journals.tubitak.gov.tr/veterinary/vol42/iss5/10/
dc.identifier.urihttps://hdl.handle.net/11468/12993
dc.identifier.volume42en_US
dc.identifier.wosWOS:000447163600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAltan, Semih
dc.institutionauthorAltan, Feray
dc.language.isoenen_US
dc.publisherTUBITAKen_US
dc.relation.ispartofTurkish Journal of Veterinary and Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGhrelinen_US
dc.subjectLamben_US
dc.subjectMotilinen_US
dc.subjectPostoperative ileusen_US
dc.titleThe effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileusen_US
dc.titleThe effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus
dc.typeArticleen_US

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