Immune activity of Ki-67 during nasal polyp development

Basit Öğe Kaydı
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-9714-4670en_US
dc.contributor.authorHaznedar, Berzan
dc.contributor.authorKaplan, Özge
dc.contributor.authorAşır, Fırat
dc.contributor.authorErmiş, Işılay Sezen
dc.date.accessioned2024-03-04T10:43:39Z
dc.date.available2024-03-04T10:43:39Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: Nasal polyps are non-cancerous, soft painless growth of nasal mucosa. In this study, our aim was to investigate the Ki-67 expression level in nasal polyps by immunohistochemical method. PATIENTS AND METHODS: 30 patients with nasal polyps were included in this study. Nasal polyps were processed for paraffin wax embedding protocol. Samples were fixed and embedded in paraffin blocks. 5 µm sections were stained with Hematoxylin-Eosin dye and immune stained with Ki-67 antibody. Sections were analyzed under light microscope. RESULTS: Blood parameters showed that white blood cells, hematocrit and platelet were higher than normal range. In sections of hematoxylin-eosin staining, elevated basal cells, thin basement membrane, leukocyte infiltration, collagen fibers degeneration were observed. Masson trichrome staining revealed that degenerative epithelial cells, detached basement membrane and edema were observed. Ki-67 expression was observed in mucosal epithelial cells, vascular endothelial cells and plasma cells in immune staining. CONCLUSIONS: Epithelial degeneration in nasal polyps and leukocyte infiltration induce nasal adenoma. Ki-67 expression may be a diagnostic tool for epithelial leukocyte formation.en_US
dc.identifier.citationHaznedar, B., Kaplan, Ö., Aşır, F. ve Ermiş, I.S. (2023). Immune activity of Ki-67 during nasal polyp development. European Review for Medical and Pharmacological Sciences, 27(7), 2759-2764.en_US
dc.identifier.doi10.26355/eurrev_202304_31904
dc.identifier.endpage2764en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid37070875
dc.identifier.scopus2-s2.0-85152974951
dc.identifier.scopusqualityQ2
dc.identifier.startpage2759en_US
dc.identifier.urihttps://www.europeanreview.org/wp/wp-content/uploads/2759-2764-1.pdf
dc.identifier.urihttps://hdl.handle.net/11468/13480
dc.identifier.volume27en_US
dc.identifier.wosWOS:000981040900008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAşır, Fırat
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDegenerationen_US
dc.subjectInflammationen_US
dc.subjectKi-67en_US
dc.subjectNasal polypen_US
dc.titleImmune activity of Ki-67 during nasal polyp developmenten_US
dc.titleImmune activity of Ki-67 during nasal polyp development
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Immune activity of Ki-67 during nasal polyp development.pdf
Boyut:
930.48 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu