The effect of resistant hypertension on in-hospital mortality in patients hospitalized with COVID-19

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dc.authorid0000-0001-6560-5746en_US
dc.contributor.authorIşık, Ferhat
dc.contributor.authorÇap, Murat
dc.contributor.authorAkyüz, Abdurrahman
dc.contributor.authorBilge, Önder
dc.contributor.authorAslan, Burhan
dc.contributor.authorİnci, Ümit
dc.contributor.authorKaya, İlyas
dc.contributor.authorTaştan, Ercan
dc.contributor.authorOkşul, Metin
dc.contributor.authorÇap, Neşe Kanbal
dc.contributor.authorKaragöz, Ali
dc.contributor.authorBaysal, Erkan
dc.date.accessioned2021-08-19T12:48:26Z
dc.date.available2021-08-19T12:48:26Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionWOS:000681541900001
dc.descriptionPMID34354253
dc.description.abstractHypertension is a major concomitant disease in hospitalized patients with COVID-19 (Coronavirus disease 2019) infection. The adverse effect of hypertension on prognosis in COVID-19 is known. Nevertheless, it is not known how COVID-19 progresses in resistant hypertensive patients. In this study, we aimed to examine the effect of resistant hypertension (ResHT) on in-hospital mortality in patients hospitalized with COVID-19. In our single-center retrospective study, included 1897 COVID-19 patients. The patients were divided into three groups according to the non-hypertensive (n = 1211), regulated HT (RegHT) (n = 574), and ResHT (n = 112). These three groups were compared according to demographic features, clinical signs, laboratory findings, and follow-up times. The median age of the study population was 62 (50–72 IQR) and 1000 (52.7%) of patients were male. The total mortality of the study population was 18.7% (n = 356). Mortality rates were similar in the hypertensive patient group (27.5% for the RegHT and 32.1% for ResHT, p = 0.321). In a multivariable analysis, ResHT was independently associated with a significantly increased risk of inhospital mortality of COVID-19, while no significant increased risk was observed with RegHT [respectively, Odds Ratio (OR) = 2.013, Confidence Interval (CI) 1.085–3.734, p = 0.026 and OR = 1.194, CI 0.795–1.794, p = 0.394]. Also, age, male gender, chronic renal failure, lymphocyte, procalcitonin, creatinine, and admission SpO2 levels were determined as independent predictors of in-hospital mortality. In our study, it was found that ResHT was an independent predictor of mortality in patients hospitalized with COVID-19; however, this situation was not found in RegHT.en_US
dc.identifier.citationIşık, F., Çap, M., Akyüz, A., Bilge, Ö., Aslan, B., İnci, Ü. ve diğerleri. (2021). The effect of resistant hypertension on in-hospital mortality in patients hospitalized with COVID-19. Journal of Human Hypertension, Early Accessen_US
dc.identifier.doi10.1038/s41371-021-00591-8
dc.identifier.endpage6en_US
dc.identifier.issn0950-9240
dc.identifier.issn1476-5527
dc.identifier.pmid34354253
dc.identifier.scopus2-s2.0-85111904644
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.nature.com/articles/s41371-021-00591-8.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7361
dc.identifier.volumeEarly Accessen_US
dc.identifier.wosWOS:000681541900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇap, Neşe Kanbal
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofJournal of Human Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypertensionen_US
dc.subjectHipertansiyonen_US
dc.subjectCOVID-19en_US
dc.titleThe effect of resistant hypertension on in-hospital mortality in patients hospitalized with COVID-19en_US
dc.titleThe effect of resistant hypertension on in-hospital mortality in patients hospitalized with COVID-19
dc.typeArticleen_US

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