A GC-MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & CA Mey. of Turkey: Enzyme inhibitory potential of ferruginol

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dc.contributor.authorBakir, Derya
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorYilmaz, Mustafa A.
dc.contributor.authorYener, Ismail
dc.contributor.authorFirat, Mehmet
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2024-04-24T17:11:43Z
dc.date.available2024-04-24T17:11:43Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, a GC-MS method used for quantitative screening of 26 compounds (sclareolide, sclareol, ferruginol, cryptanol, 6,7-dehydroroyleanone, suginal, 9,10-dihydro-7,8-dimethyl-2-(1-methylethyl) phenanthren-3-ol, sugiol, inuroyleanone, 12-demethylmulticauline, 7 alpha-hydroxy-beta-sitosterol, stigmasterol, sitosterol, salvigenin, sinensetin,alpha-amyrin, lupeol, lupenone, 3-acetyl lupeol, 1 alpha,21 alpha-dihydroxy-2,3-(1 ' 1 '-dimethyl-dioxymethylene) urs-9(11),12-dien, uvaol, betulin, pyxinol, lup-(20),29-ene-2 alpha-hydroxy-3 beta-acetate, betulin 3 beta, 28 beta-diacetate, 21 alpha-hydroxy,2 alpha,3 beta-diacetoxy urs-9(11),12-dien) specific to TurkishSalviaspecies was developed and validated. According to the GC-MS analysis results,Salvia hypargeiaFisch. & C.A. Mey. roots were found to be rich in ferruginol (30787.97 mu g/g extract) and lupenone (23276.21 mu g/g extract), and leaves in lupeol (20625.92 mu g/g extract). Additionally, the essential oil and aroma contents of this species were identified by GC-MS technique. According to the LC-MS/MS results, especiallyS. hypargeialeaf extract was rich in rosmarinic acid (38035.7 mu g/g extract) and isoquercitrin (4136.91 mu g/g extract). Furthermore, anticholinesterase, antiurease, antityrosinase and antielastase inhibitory, antioxidant, cytotoxic activities of the ethanol extracts, essential oil, and major components of the species were evaluated. Antioxidant potentials of all extracts of this species were quite high in all studied antioxidant methods. Moreover, butyrylcholinesterase and elastase inhibitory capacities of ferruginol, the major component ofS. hypargeiaroots, were notable. For these reasons, this species has a high potential for food and pharmaceutical industries. Practical applications This new GC-MS method was applied toS. hypargeiaFisch. & C.A. Mey. and it indicated that this species possessed high amount of ferruginol and lupeol, and that this species could be used for their natural sources. According to the results of the activity studies (antioxidant, anticholinesterase, tyrosinase, elastase, and cytotoxic), this method was used to exhibit which compound may be responsible for the activities. This developed and validated method could be easily applied to determine major/active/toxic secondary metabolites ofSalviaspecies which are used and/or could be used in pharmaceutical, cosmetic, and food industries.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [KBAG114Z801]; Dicle Universitesi [ECZACILIK.20.001]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK), Grant/Award Number: KBAG114Z801; Dicle Universitesi, Grant/Award Number: ECZACILIK.20.001en_US
dc.identifier.doi10.1111/jfbc.13350
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue9en_US
dc.identifier.pmid32686189
dc.identifier.scopus2-s2.0-85088087359
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jfbc.13350
dc.identifier.urihttps://hdl.handle.net/11468/17690
dc.identifier.volume44en_US
dc.identifier.wosWOS:000549841500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEssential Oilen_US
dc.subjectFerruginolen_US
dc.subjectGc-Ms Method Validationen_US
dc.subjectLc-Msen_US
dc.subjectMsen_US
dc.subjectSalvia Hypargeiaen_US
dc.subjectTerpenoiden_US
dc.titleA GC-MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & CA Mey. of Turkey: Enzyme inhibitory potential of ferruginolen_US
dc.titleA GC-MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & CA Mey. of Turkey: Enzyme inhibitory potential of ferruginol
dc.typeArticleen_US

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