Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II

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dc.authorid0000-0002-4337-9327en_US
dc.contributor.authorVarışli, Lokman
dc.contributor.authorDancik, Garrett M.
dc.contributor.authorCopland, John A.
dc.contributor.authorVlahopoulos, Spiros A.
dc.date.accessioned2025-01-16T06:07:44Z
dc.date.available2025-01-16T06:07:44Z
dc.date.issued06.01.2025en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractAcute leukemia is a wide group of hematologic malignancies that arise from leukemiainitiating cells (LICs), also known as leukemic stem cells (LSCs), which originate from transformed hematopoietic stem cells (HSCs) in the bone marrow. Leukemic cells accumulate various genetic and epigenetic defects, both inherited from the LICs they originate from and acquired later. Genetic defects in leukemic cells determine their biological behavior and, as expected, affect the prognosis of the disease and its response to treatment. Therefore, molecular characterization of the disease is important for all stages of the disease, such as predicting prognosis, determining the treatment approach, and evaluating the possibility of recurrence. In this context, a better understanding of the molecular mechanisms of acute leukemia will enable the emergence of simpler and more effective treatment approaches and increase the rate of treated patients.en_US
dc.identifier.citationVarışli, L, Dancik, G.M., Copland, J.A. and Vlahopoulos, S.A. (2025). Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II. Frontiers in Oncology, 1-3.en_US
dc.identifier.pmidPMID: 37234979
dc.identifier.scopus2-s2.0-85215306406
dc.identifier.scopusqualityQ2
dc.identifier.startpage1542306en_US
dc.identifier.urihttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1542306/full
dc.identifier.urihttps://hdl.handle.net/11468/29375
dc.identifier.volume14en_US
dc.identifier.wosWOS:000994180700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorVarışli, Lokman
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers in Oncology
dc.relation.isversionof10.3389/fonc.2024.1542306en_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute leukemiasen_US
dc.subjectLeukemia stem cellsen_US
dc.subjectTissue microenvironmenten_US
dc.subjectImmunityen_US
dc.subjectInflammationen_US
dc.subjectHomeostasisen_US
dc.subjectStress responseen_US
dc.titleEditorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume IIen_US
dc.titleEditorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II
dc.typeEditorialen_US

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