Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II
Yükleniyor...
Dosyalar
Tarih
06.01.2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Frontiers
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Acute leukemia is a wide group of hematologic malignancies that arise from leukemiainitiating
cells (LICs), also known as leukemic stem cells (LSCs), which originate from
transformed hematopoietic stem cells (HSCs) in the bone marrow. Leukemic cells
accumulate various genetic and epigenetic defects, both inherited from the LICs they
originate from and acquired later. Genetic defects in leukemic cells determine their
biological behavior and, as expected, affect the prognosis of the disease and its response
to treatment. Therefore, molecular characterization of the disease is important for all stages
of the disease, such as predicting prognosis, determining the treatment approach, and
evaluating the possibility of recurrence. In this context, a better understanding of the
molecular mechanisms of acute leukemia will enable the emergence of simpler and more
effective treatment approaches and increase the rate of treated patients.
Açıklama
Anahtar Kelimeler
Acute leukemias, Leukemia stem cells, Tissue microenvironment, Immunity, Inflammation, Homeostasis, Stress response
Kaynak
Frontiers in Oncology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
14
Sayı
Künye
Varışli, L, Dancik, G.M., Copland, J.A. and Vlahopoulos, S.A. (2025). Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment, volume II. Frontiers in Oncology, 1-3.
