Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)

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dc.authorid0000-0002-9017-763Xen_US
dc.contributor.authorÇorum, Orhan
dc.contributor.authorÇorum, Duygu Durna
dc.contributor.authorAltan, Feray
dc.contributor.authorEr, Ayşe
dc.contributor.authorÇetin, Gül
dc.contributor.authorÜney, Kamil
dc.date.accessioned2021-09-14T13:11:02Z
dc.date.available2021-09-14T13:11:02Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Farmakoloji ve Toksikoloji Ana Bilim Dalıen_US
dc.descriptionPMID:30853667
dc.description.abstractThis study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t1/2 ʎ z), mean residence time (MRT0-∞), area under the concentration-time curve (AUC0-∞), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr·μg/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2ʎz, MRT0-∞AUC0-∞,peak concentration (Cmax), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr·μg/ml, 8.75 μg/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.en_US
dc.identifier.citationÇorum, O., Çorum, D. D., Altan, F., Er, A., Çetin, G., Üney, K. ve diğerleri. (2019). Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans). Journal of Veterinary Medical Science, 81(5), 753-757.en_US
dc.identifier.doi10.1292/jvms.18-0609
dc.identifier.endpage757en_US
dc.identifier.issn0916-7250
dc.identifier.issue5en_US
dc.identifier.pmid30853667
dc.identifier.scopus2-s2.0-85067099075
dc.identifier.scopusqualityQ2
dc.identifier.startpage753en_US
dc.identifier.urihttps://www.jstage.jst.go.jp/article/jvms/81/5/81_18-0609/_article
dc.identifier.urihttps://hdl.handle.net/11468/7582
dc.identifier.volume81en_US
dc.identifier.wosWOS:000472005900021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltan, Feray
dc.language.isoenen_US
dc.publisherJapanese Society of Veterinary Scienceen_US
dc.relation.ispartofJournal of Veterinary Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBioavailabilityen_US
dc.subjectDanofloxacinen_US
dc.subjectPharmacokineticsen_US
dc.subjectRed-eared slider turtlesen_US
dc.titlePharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)en_US
dc.titlePharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)
dc.typeArticleen_US

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