Metformin HCl has curative effect on rebuilding of ventricular diastolic functions in high-fat-diet fed rats

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dc.contributor.authorTopal, Askin Ender
dc.contributor.authorKelle, Ilker
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorYilmaz, Sedat
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-04-24T17:37:38Z
dc.date.available2024-04-24T17:37:38Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractMyocardial lipid accumulation due to diabetes and/or obesity plays a role in the progression of left ventricular diastolic dysfunction. Our aims were to exhibit the correlation between histopathologic stage of the liver and cardiac functions, and to evaluate the effects of metformin HC1 and rosiglitazone on myocardial functions. Thirty-two male Sprague-Dawley rats were divided into four groups to exhibit the correlation between histopathologic stage of the liver and cardiac functions and to determine whether metformin HC1 and rosiglitazone have effects on cardiac functions. For 20 weeks, one group was fed standard rat basic diet, whereas the other groups were on high-fat-diet. During the last 4 weeks, metformin HC1 was given to the third group, rosiglitazone to the fourth group. Histological evaluation of rat livers yielded significantly higher steatosis grade in high-fat-diet group and different fibrosis stages among groups. Also, there was significant correlation between diastolic functions and steatosis grade/fibrosis stage of rat liver. Electrophysiological study of hearts via Langendorff technique showed better coronary perfusion pressures and diastolic functions in standard -diet and metformin HC1 groups compared to other groups. Metformin HC1 improves LV diastolic dysfunction and coronary perfusion pressures.en_US
dc.identifier.endpage954en_US
dc.identifier.issn1011-601X
dc.identifier.issue3en_US
dc.identifier.pmid28655690en_US
dc.identifier.scopus2-s2.0-85064722142en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage949en_US
dc.identifier.urihttps://hdl.handle.net/11468/21090
dc.identifier.volume30en_US
dc.identifier.wosWOS:000405541000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMyocardial Steatosisen_US
dc.subjectMetformin Hc1en_US
dc.subjectRosiglitazoneen_US
dc.subjectDiastolic Dysfunctionen_US
dc.subjectCoronary Perfusion.en_US
dc.titleMetformin HCl has curative effect on rebuilding of ventricular diastolic functions in high-fat-diet fed ratsen_US
dc.typeArticleen_US

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