Metformin HCl has curative effect on rebuilding of ventricular diastolic functions in high-fat-diet fed rats
[ X ]
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Karachi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Myocardial lipid accumulation due to diabetes and/or obesity plays a role in the progression of left ventricular diastolic dysfunction. Our aims were to exhibit the correlation between histopathologic stage of the liver and cardiac functions, and to evaluate the effects of metformin HC1 and rosiglitazone on myocardial functions. Thirty-two male Sprague-Dawley rats were divided into four groups to exhibit the correlation between histopathologic stage of the liver and cardiac functions and to determine whether metformin HC1 and rosiglitazone have effects on cardiac functions. For 20 weeks, one group was fed standard rat basic diet, whereas the other groups were on high-fat-diet. During the last 4 weeks, metformin HC1 was given to the third group, rosiglitazone to the fourth group. Histological evaluation of rat livers yielded significantly higher steatosis grade in high-fat-diet group and different fibrosis stages among groups. Also, there was significant correlation between diastolic functions and steatosis grade/fibrosis stage of rat liver. Electrophysiological study of hearts via Langendorff technique showed better coronary perfusion pressures and diastolic functions in standard -diet and metformin HC1 groups compared to other groups. Metformin HC1 improves LV diastolic dysfunction and coronary perfusion pressures.
Açıklama
Anahtar Kelimeler
Myocardial Steatosis, Metformin Hc1, Rosiglitazone, Diastolic Dysfunction, Coronary Perfusion.
Kaynak
Pakistan Journal of Pharmaceutical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
30
Sayı
3
