Evaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized rats

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dc.authorid0000-0002-4129-0564en_US
dc.authorid0000-0001-9898-0593en_US
dc.contributor.authorKadiroğlu, Ela Tules
dc.contributor.authorKarayürek, Fatih
dc.contributor.authorAkbalık, Mehmet Erdem
dc.date.accessioned2021-08-27T07:08:38Z
dc.date.available2021-08-27T07:08:38Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Bölümüen_US
dc.description.abstractBone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: Control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal bone using a trephine dental drill and a physiodispenser with saline. All animals were euthanized at the end of week 8, and bone tissues were analyzed histologically and immunohistochemically. The allografts produced better results in terms of calvarial defect healing in both the ovariectomized and nonovariectomized groups compared to the control group in enhancing bone healing, whereas BMPs combined with allografts had no positive effect on new bone formation. The allografts and BMPs applied in both groups produced fibrous tissues rather than new bone tissue. Further comprehensive studies on the effectiveness of BMPs in the formation of new bone tissue should be conducted in animals with estrogen deficiency.en_US
dc.identifier.citationKadiroğlu, E. T., Karayürek, F. ve Akbalık, M. E. (2020). Evaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized rats. Turkish Journal of Veterinary and Animal Sciences, 44,548-561.en_US
dc.identifier.doi10.3906/vet-1911-24
dc.identifier.endpage561en_US
dc.identifier.issn1300-0128
dc.identifier.scopus2-s2.0-85084312400
dc.identifier.scopusqualityQ3
dc.identifier.startpage548en_US
dc.identifier.trdizinid353915
dc.identifier.urihttps://journals.tubitak.gov.tr/veterinary/issues/vet-20-44-3/vet-44-3-10-1911-24.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7402
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/353915
dc.identifier.volume44en_US
dc.identifier.wosWOS:000538112800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKadiroğlu, Ela Tules
dc.institutionauthorAkbalık, Mehmet Erdem
dc.language.isoenen_US
dc.publisherTUBITAKen_US
dc.relation.ispartofTurkish Journal of Veterinary and Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllograften_US
dc.subjectBone morphogenetic proteinen_US
dc.subjectBone regenerationen_US
dc.subjectOvariectomyen_US
dc.subjectRaten_US
dc.titleEvaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized ratsen_US
dc.titleEvaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized rats
dc.typeArticleen_US

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