Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?

Basit Öğe Kaydı
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorGuclu, Orkut
dc.contributor.authorYazici, Suleyman
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYavuz, Celal
dc.contributor.authorMavitas, Binali
dc.date.accessioned2024-04-24T17:15:09Z
dc.date.available2024-04-24T17:15:09Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature. Material/Methods: The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model. Four different concentrations (10-7, 10-6, 10-5, and 10-4 M) of drug pellet were prepared for each drug. Changes in vessel formation were scored and compared for each drug according to the previous literature. Result: The antiangiogenic behavior of CaD was lower than Bb, despite the significant dose-dependent manner of escalation. The anti-angiogenic scores of CaD were determined as 0.20, 0.47, 0.66, 1.0 in 10-7, 10-6, 10-5, and 10-4 M concentrations, respectively (average score >0.5 was significant). Conclusions: According to the data obtained, this agent should be used carefully for cases in which angiogenesis plays an important role in healing.en_US
dc.identifier.doi10.12659/MSMBR.889427
dc.identifier.endpage257en_US
dc.identifier.issn2325-4416
dc.identifier.issn2325-4394
dc.identifier.pmid24072135
dc.identifier.scopus2-s2.0-84923056908
dc.identifier.scopusqualityQ1
dc.identifier.startpage253en_US
dc.identifier.urihttps://doi.org/10.12659/MSMBR.889427
dc.identifier.urihttps://hdl.handle.net/11468/18352
dc.identifier.volume19en_US
dc.identifier.wosWOS:000218474100036
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Literature, Incen_US
dc.relation.ispartofMedical Science Monitor Basic Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalcium Dobesilateen_US
dc.subjectAngiogenesisen_US
dc.subjectDose-Dependent Actionen_US
dc.subjectChorioallantoic Membrane Modelen_US
dc.titleCan calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?en_US
dc.titleCan calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu