Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?

[ X ]

Tarih

2013

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Int Scientific Literature, Inc

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background: Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature. Material/Methods: The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model. Four different concentrations (10-7, 10-6, 10-5, and 10-4 M) of drug pellet were prepared for each drug. Changes in vessel formation were scored and compared for each drug according to the previous literature. Result: The antiangiogenic behavior of CaD was lower than Bb, despite the significant dose-dependent manner of escalation. The anti-angiogenic scores of CaD were determined as 0.20, 0.47, 0.66, 1.0 in 10-7, 10-6, 10-5, and 10-4 M concentrations, respectively (average score >0.5 was significant). Conclusions: According to the data obtained, this agent should be used carefully for cases in which angiogenesis plays an important role in healing.

Açıklama

Anahtar Kelimeler

Calcium Dobesilate, Angiogenesis, Dose-Dependent Action, Chorioallantoic Membrane Model

Kaynak

Medical Science Monitor Basic Research

WoS Q Değeri

N/A

Scopus Q Değeri

Q1

Cilt

19

Sayı

Künye