Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Scientific Literature, Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature. Material/Methods: The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model. Four different concentrations (10-7, 10-6, 10-5, and 10-4 M) of drug pellet were prepared for each drug. Changes in vessel formation were scored and compared for each drug according to the previous literature. Result: The antiangiogenic behavior of CaD was lower than Bb, despite the significant dose-dependent manner of escalation. The anti-angiogenic scores of CaD were determined as 0.20, 0.47, 0.66, 1.0 in 10-7, 10-6, 10-5, and 10-4 M concentrations, respectively (average score >0.5 was significant). Conclusions: According to the data obtained, this agent should be used carefully for cases in which angiogenesis plays an important role in healing.
Açıklama
Anahtar Kelimeler
Calcium Dobesilate, Angiogenesis, Dose-Dependent Action, Chorioallantoic Membrane Model
Kaynak
Medical Science Monitor Basic Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
19
