The immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cows

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dc.authorid0000-0001-5489-2719en_US
dc.authorid0000-0002-5456-697Xen_US
dc.contributor.authorLiman, Narin
dc.contributor.authorSağsöz, Hakan
dc.date.accessioned2023-09-27T06:35:10Z
dc.date.available2023-09-27T06:35:10Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe adherens junctions (AJs) maintain the epithelial cell layers' structural integrity and barrier function. AJs also play a vital role in various biological and pathological processes. AJs perform these functions through the cadherin-catenin adhesion complex. This study investigated the presence, cell-specific localization, and temporal distribution of AJ components such as classical type I cadherins and beta-catenin in the cow cervix and vagina during the estrous cycle. Immunohistochemistry and Western blot analysis results demonstrated that beta-catenin and epithelial (E)-, neural (N)-, and placental (P)-cadherins are expressed in the cow cervix and vagina during the estrous cycle. These adhesion molecules were localized in the membrane and cytoplasm of the ciliated and non-ciliated cervical cells and the stratified vaginal epithelial cells. Positive immunostaining for P-, N-cadherin, and beta-catenin was also observed in the vascular endothelial cells of the cervical and vaginal stroma. Quantitative immunohistochemistry examinations revealed that in the cervical and vaginal epithelia, P-cadherin's optical density values (ODv) were the highest; in contrast, the N-cadherin ODv were the lowest. The ODv of P-cadherin and beta-catenin in the cervical epithelium and E-cadherin in the vagina were significantly higher in the luteal phase versus the follicular phase of the estrous cycle. Furthermore, the ODv of P-cadherin, N-cadherin, and beta-catenin in the cervix's central and peripheral epithelial regions were different during the estrous cycle. These findings indicate that classical cadherins and beta-catenin in the cervix and vagina exhibit cell- and tissue-specific expression patterns under the influence of estrogen and progesterone hormones during the estrous cycle.en_US
dc.identifier.citationLiman, N. ve Sağsöz, H. (2023). The immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cows. Veterinary Research Communications, 47(3), 1155-1175.en_US
dc.identifier.doi10.1007/s11259-023-10075-4
dc.identifier.endpage1175en_US
dc.identifier.issn0165-7380
dc.identifier.issue3en_US
dc.identifier.pmid36729278
dc.identifier.scopus2-s2.0-85147283934
dc.identifier.scopusqualityQ2
dc.identifier.startpage1155en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11259-023-10075-4
dc.identifier.urihttps://hdl.handle.net/11468/12613
dc.identifier.volume47en_US
dc.identifier.wosWOS:000924680300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSağsöz, Hakan
dc.language.isoenen_US
dc.publisherSpringer Science and Business Mediaen_US
dc.relation.ispartofVeterinary Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-cateninen_US
dc.subjectBovineen_US
dc.subjectCadherinen_US
dc.subjectCervixen_US
dc.subjectVaginaen_US
dc.titleThe immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cowsen_US
dc.titleThe immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cows
dc.typeArticleen_US

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