Phytochemical profiling and biological activity of Achillea sintenisii Hub.-Mor

Yükleniyor...
Küçük Resim

Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

John Wiley and Sons Inc.

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 μg/mg extract) and chlorogenic acid (14.97 μg/mg extract) were identified as main constituents of the extract.

Açıklama

Anahtar Kelimeler

Achillea, Phytochemicals, Antioxidant, Chlorogenic acid

Kaynak

Chemistry and Biodiversity

WoS Q Değeri

N/A

Scopus Q Değeri

Q3

Cilt

20

Sayı

6

Künye

Eruygur, N., Büyükyıldırım, T., Rama, Ş. T., Ayaz, F., Tekin, M., Tuzcu, M. ve diğerleri. (2023). Phytochemical profiling and biological activity of Achillea sintenisii Hub.-Mor. Chemistry and Biodiversity, 20(6), 1-9.