Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study

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dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0002-1680-907Xen_US
dc.authorid0000-0002-0549-8472en_US
dc.authorid0000-0002-0166-9668en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-1693-6378en_US
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorDeveci, Engin
dc.contributor.authorSak, Erdal
dc.contributor.authorEvsen, Sıddık
dc.contributor.authorTunik, Selçuk
dc.contributor.authorNergiz, Şebnem
dc.contributor.authorAşır, Fırat
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2024-03-06T13:26:13Z
dc.date.available2024-03-06T13:26:13Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is generally considered to be a variant or complication of preeclampsia. It is a life-threatening obstetric complication. Objectives: To evaluate the immunohistochemistry and ultrastructural of syncytiotrophoblastand Hoffbauer cells in placental villi of patients with HELLP syndrome. Methods: Two groups of patients with a total of 50 full-term human placentas (n = 25 in each group) were assigned as the control (normotensive) and HELLP syndrome. Placental tissue samples were fixed in 10% neutral formalin and paraffin-embedding protocol was performed. We prepared 5 μm sections for histological and immunohistochemical staining. Sections were immunostained with Hoffbauer cell marker CD68. For transmission electron microscopy (TEM), placental tissue samples were fixed in 2.5% buffered glutaraldehyde and then, in 1% osmium tetroxide for routine ultrastructural examinations. Results: When the HELLP group fetal placental sections were examined, intracytoplasmic edema in syncytiotrophoblast, degenerative vacuoles, and degenerative findings on cell surface membranes were observed. Moreover, villous edema was remarkable. The number of CD68-positive Hoffbauer cells per villus control group sections was 0.23 ± 0.02 and the number of CD68-positive cells per villus in HELLP group placenta sections was 0.83 ± 0.12. The increase in the number of Hoffbauer cells per villus in the HELLP group was significant (P < 0.001). Compared with the control group, there was a significant increase in the number of Hoffbauer cells and syncytiotrophoblasts in the HELLP group, and degenerative changes were also observed in the ultrastructure of these cells. Conclusions: Pathology of the HELLP syndrome is in relation to CD68-positive placental macrophages.en_US
dc.identifier.citationNergiz, Y., Deveci, E., Sak, E., Evsen, S., Tunik, S., Nergiz, Ş. ve diğerleri. (2023). Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study. Asian Biomedicine, 17(5), 238-243.en_US
dc.identifier.doi10.2478/abm-2023-0065
dc.identifier.endpage243en_US
dc.identifier.issn1905-7415
dc.identifier.issue5en_US
dc.identifier.pmid37899759
dc.identifier.scopus2-s2.0-85176328901
dc.identifier.scopusqualityQ4
dc.identifier.startpage238en_US
dc.identifier.urihttps://sciendo.com/article/10.2478/abm-2023-0065
dc.identifier.urihttps://hdl.handle.net/11468/13546
dc.identifier.volume17en_US
dc.identifier.wosWOS:001105153400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNergiz, Yusuf
dc.institutionauthorDeveci, Engin
dc.institutionauthorSak, Erdal
dc.institutionauthorEvsen, Sıddık
dc.institutionauthorTunik, Selçuk
dc.institutionauthorNergiz, Şebnem
dc.institutionauthorAşır, Fırat
dc.institutionauthorŞeker, Uğur
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofAsian Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHELLP syndromeen_US
dc.subjectHoffbauer cellen_US
dc.subjectImmunohistochemistryen_US
dc.subjectPlacentaen_US
dc.subjectSyncytiotrophoblasten_US
dc.titleSevere preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical studyen_US
dc.titleSevere preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study
dc.typeArticleen_US

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