The effect of benzalkonium chloride on rabbit nasal mucosa in vivo

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dc.contributor.authorCüreoglu, S
dc.contributor.authorAkkus, M
dc.contributor.authorOsma, Ü
dc.contributor.authorYaldiz, M
dc.contributor.authorOktay, F
dc.contributor.authorCan, B
dc.contributor.authorGüven, C
dc.date.accessioned2024-04-24T16:00:19Z
dc.date.available2024-04-24T16:00:19Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study we investigated the histopathological changes of nasal mucosa after the use of topical benzalkonium-chloride solution. In the study, 28 male New Zealand white rabbits were used. The animals were divided into two groups. In the first group, 50 mul of 0.001% benzalkonium-chloride solution was sprayed into the right nostril and 50 mul of 0.9% saline into the left twice daily for 14 days. In the second group, the same solutions were applied twice daily for 28 days. All of the biopsies from each nasal cavity were processed for electron microscopy. In the nostrils treated with 0.001% benzalkonium chloride, there were areas with obvious squamous cell metaplasia. Some cells showed broken cristae of the mitochondria. Degenerative changes in the supportive and olfactory cells, deformation of nuclei and the increase of heterochromatin were observed. The present investigation has shown that the application of topical benzalkonium chloride does induce degenerative morphologic changes in the nasal mucosa in rabbits in vivo.en_US
dc.identifier.doi10.1007/s00405-002-0458-x
dc.identifier.endpage364en_US
dc.identifier.issn0937-4477
dc.identifier.issue7en_US
dc.identifier.pmid12189401
dc.identifier.scopus2-s2.0-0036375377
dc.identifier.scopusqualityQ1
dc.identifier.startpage362en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-002-0458-x
dc.identifier.urihttps://hdl.handle.net/11468/14436
dc.identifier.volume259en_US
dc.identifier.wosWOS:000177893700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzalkonium Chlorideen_US
dc.subjectPreservativeen_US
dc.subjectNasal Mucosaen_US
dc.subjectTopical Nasal Decongestantsen_US
dc.subjectSteroidsen_US
dc.titleThe effect of benzalkonium chloride on rabbit nasal mucosa in vivoen_US
dc.titleThe effect of benzalkonium chloride on rabbit nasal mucosa in vivo
dc.typeArticleen_US

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