The effect of benzalkonium chloride on rabbit nasal mucosa in vivo
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Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study we investigated the histopathological changes of nasal mucosa after the use of topical benzalkonium-chloride solution. In the study, 28 male New Zealand white rabbits were used. The animals were divided into two groups. In the first group, 50 mul of 0.001% benzalkonium-chloride solution was sprayed into the right nostril and 50 mul of 0.9% saline into the left twice daily for 14 days. In the second group, the same solutions were applied twice daily for 28 days. All of the biopsies from each nasal cavity were processed for electron microscopy. In the nostrils treated with 0.001% benzalkonium chloride, there were areas with obvious squamous cell metaplasia. Some cells showed broken cristae of the mitochondria. Degenerative changes in the supportive and olfactory cells, deformation of nuclei and the increase of heterochromatin were observed. The present investigation has shown that the application of topical benzalkonium chloride does induce degenerative morphologic changes in the nasal mucosa in rabbits in vivo.
Açıklama
Anahtar Kelimeler
Benzalkonium Chloride, Preservative, Nasal Mucosa, Topical Nasal Decongestants, Steroids
Kaynak
European Archives of Oto-Rhino-Laryngology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
259
Sayı
7
