Bone mineral density in children with beta-thalassemia major in Diyarbakir

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dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0001-8463-2723en_US
dc.authorid0000-0002-2524-2124en_US
dc.authorid0000-0002-2435-7800en_US
dc.contributor.authorPirinççioğlu, Ayfer Gözü
dc.contributor.authorAkpolat, Veysi
dc.contributor.authorKöksal, Orhan
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorSöker, Murat
dc.date.accessioned2021-12-03T12:10:58Z
dc.date.available2021-12-03T12:10:58Z
dc.date.issued2011en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBone mineral status has extensively been investigated in adult thalassemics but less in thalassemic children. This study involves measurements of the bone mineral density (BMD), various demographic and biochemical parameters in 47 thalassemic children and 50 healthy controls with comparable age, sex, socioeconomic and regional distribution. Patients have significantly higher aspartate aminotransferase, alanine aminotransferase, phosphorous, osteocalcin, serum carboxy terminal teleopeptide fragment of type I collagen, intact parathyroid hormone (iPTH) and ferritin levels while they have significantly lower 25-hydroxy vitamin D (25OH-D), alkaline phosphatase and z-scores both at lumbar and femur compared to controls. Patients with high iPTH (30%) had significantly lower z-scores and 25OH-D while larger osteocalcin. We conclude that a significantly lower BMD in beta-thalassemic children compared with their healthy counterparts is a complex process and may partially attributed to their slower physical development, caused by iron overload and chelation therapy which may influence the liver as well as the endocrine tissues.en_US
dc.identifier.citationPirinççioğlu, A. G., Akpolat, V., Köksal, O., Haspolat, Y. K. ve Söker, M. (2011). Bone mineral density in children with beta-thalassemia major in Diyarbakir. Bone, 49(4), 819-823.en_US
dc.identifier.doi10.1016/j.bone.2011.07.014
dc.identifier.endpage823en_US
dc.identifier.issn8756-3282
dc.identifier.issue4en_US
dc.identifier.pmid21798385
dc.identifier.scopus2-s2.0-80052296789
dc.identifier.scopusqualityQ1
dc.identifier.startpage819en_US
dc.identifier.urihttps://hdl.handle.net/11468/8353
dc.identifier.volume49en_US
dc.identifier.wosWOS:000295240200028
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPirinççioğlu, Ayfer Gözü
dc.institutionauthorAkpolat, Veysi
dc.institutionauthorKöksal, Orhan
dc.institutionauthorHaspolat, Yusuf Kenan
dc.institutionauthorSöker, Murat
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBone
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone mineral densityen_US
dc.subjectChildrenen_US
dc.subjectOsteoporosisen_US
dc.subjectOsteopeniaen_US
dc.subjectBeta-thalassemiaen_US
dc.titleBone mineral density in children with beta-thalassemia major in Diyarbakiren_US
dc.titleBone mineral density in children with beta-thalassemia major in Diyarbakir
dc.typeArticleen_US

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