Bone mineral density in children with beta-thalassemia major in Diyarbakir
Yükleniyor...
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Bone mineral status has extensively been investigated in adult thalassemics but less in thalassemic children. This study involves measurements of the bone mineral density (BMD), various demographic and biochemical parameters in 47 thalassemic children and 50 healthy controls with comparable age, sex, socioeconomic and regional distribution. Patients have significantly higher aspartate aminotransferase, alanine aminotransferase, phosphorous, osteocalcin, serum carboxy terminal teleopeptide fragment of type I collagen, intact parathyroid hormone (iPTH) and ferritin levels while they have significantly lower 25-hydroxy vitamin D (25OH-D), alkaline phosphatase and z-scores both at lumbar and femur compared to controls. Patients with high iPTH (30%) had significantly lower z-scores and 25OH-D while larger osteocalcin. We conclude that a significantly lower BMD in beta-thalassemic children compared with their healthy counterparts is a complex process and may partially attributed to their slower physical development, caused by iron overload and chelation therapy which may influence the liver as well as the endocrine tissues.
Açıklama
Anahtar Kelimeler
Bone mineral density, Children, Osteoporosis, Osteopenia, Beta-thalassemia
Kaynak
Bone
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
49
Sayı
4
Künye
Pirinççioğlu, A. G., Akpolat, V., Köksal, O., Haspolat, Y. K. ve Söker, M. (2011). Bone mineral density in children with beta-thalassemia major in Diyarbakir. Bone, 49(4), 819-823.
