Epidermal growth factor receptors and their ligands are expressed in the spleen of the Japanese Quail (Coturnix coturnix japonica) during the post-hatch period

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dc.authorid0000-0003-4990-3991en_US
dc.authorid0000-0002-5456-697Xen_US
dc.authorid0000-0001-5489-2719en_US
dc.contributor.authorAlan, Emel
dc.contributor.authorLiman, Narin
dc.contributor.authorSağsöz, Hakan
dc.date.accessioned2024-03-18T10:53:11Z
dc.date.available2024-03-18T10:53:11Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstract1. The epidermal growth factor (EGF) family plays an important role in the development, differentiation, migration and apoptosis of cells, as well as in wound healing, which are all essential to the viability of multicellular organisms. The avian spleen is a principal organ of systemic immunity and its importance in disease resistance is presumably accentuated by the scarcity of avian lymph nodes. 2. The aim of this study was to determine whether EGF receptors (ErbB1-4) and their ligands (EGF, AREG and NRG) are expressed in the structural components of the quail spleen during the post-hatch period. At each selected age, from 1 d to 7, 14, 21 and 60 d, 10 quails were euthanised under ether anaesthesia and their spleens were fixed in a 10% formaldehyde-alcohol solution. Following routine histological processing, the streptavidin-biotin-peroxidase method was used for immunohistochemical examination. 3. Strong cytoplasmic immunoreactions for ErbB2, ErbB4 and NRG were observed in the ellipsoid associated cells (EAC) of the quail spleen throughout the post-hatch period. This immunoreactivity in the EAC increased after the 7th d post-hatch. ErbB1 and ErbB3 immunoreactions were relatively similar and weak in all components of the spleen during the post-hatch period. Some immune cells of the peri-arterial lymphatic sheath (PALS) and peri-ellipsoidal lymphatic sheath (PELS) showed positive immunoreactivity for the ErbB receptors and their ligands. In the vascular smooth muscle cells, immunoreactivity for ErbB2 was stronger than that for the other ErbB receptors and their ligands. 4. The data showed that ErbB receptors and their ligands (EGF, AREG and NRG) are expressed by different structural components of the quail spleen during the post-hatch period.en_US
dc.identifier.citationAlan, E., Liman, N. ve Sağsöz, H. (2023). Epidermal growth factor receptors and their ligands are expressed in the spleen of the Japanese Quail (Coturnix coturnix japonica) during the post-hatch period. British Poultry Science, 64(1), 81-89.en_US
dc.identifier.doi10.1080/00071668.2022.2121912
dc.identifier.endpage89en_US
dc.identifier.issn0007-1668
dc.identifier.issue1en_US
dc.identifier.pmid36083170
dc.identifier.scopus2-s2.0-85139756217
dc.identifier.scopusqualityQ1
dc.identifier.startpage81en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00071668.2022.2121912
dc.identifier.urihttps://hdl.handle.net/11468/13613
dc.identifier.volume64en_US
dc.identifier.wosWOS:000866355600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSağsöz, Hakan
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal growth factoren_US
dc.subjectImmunohistochemistryen_US
dc.subjectLiganden_US
dc.subjectPost-hatch perioden_US
dc.subjectQuailen_US
dc.subjectSpleenen_US
dc.titleEpidermal growth factor receptors and their ligands are expressed in the spleen of the Japanese Quail (Coturnix coturnix japonica) during the post-hatch perioden_US
dc.titleEpidermal growth factor receptors and their ligands are expressed in the spleen of the Japanese Quail (Coturnix coturnix japonica) during the post-hatch period
dc.typeArticleen_US

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