Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats

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dc.authorid0000-0002-7486-232Xen_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorLaçin, Nihat
dc.contributor.authorİzol, Serhat Bozan
dc.contributor.authorİpek, Fikret
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2021-09-28T07:21:01Z
dc.date.available2021-09-28T07:21:01Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Bölümüen_US
dc.descriptionPMID:31778526
dc.description.abstractPurpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. Methods: Wistar male rats (n = 30) were divided into 3 groups: 1) the control (defect) group (n = 10), 2) defect and graft group (n = 10), and 3) defect, graft, and G. lucidum treated group (n = 10). The G. lucidum was administered to the rats at 20 mL/kg per day via gastric lavage. Results: In the defect and graft group, osteonectin positive expression was observed in osteoblast and osteocyte cells at the periphery of the small bone trabeculae within the graft area. In the defect, graft, and G. lucidum treated group, osteonectin expression was positive in the osteoblast and osteocyte cells and positive osteonectin expression in new bone trabeculae. The expression of matrix metalloproteinase-9 (MMP-9) was positive in the inflammatory cells, fibroblast cells, and degenerated collagen fibril areas within the defect area. Conclusion: This study shows that, with its antioxidant and anti-inflammatory properties, G. Lucidum is an important factor in the treatment of calvarial bone defects.en_US
dc.identifier.citationLaçin, N., İzol, S. B., İpek, F. ve Tuncer, C. M. (2019). Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats. Acta Cirurgica Brasileira, 34(9), e201900904.en_US
dc.identifier.doi10.1590/s0102-865020190090000004
dc.identifier.issn0102-8650
dc.identifier.issue9en_US
dc.identifier.pmid31778526
dc.identifier.scopus2-s2.0-85075598675
dc.identifier.scopusqualityQ2
dc.identifier.startpagee201900904en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/Cwwc7ScK6GSYvchNPng4ZMg/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/7805
dc.identifier.volume34en_US
dc.identifier.wosWOS:000499791700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİpek, Fikret
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMatrix metalloproteinase 9en_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectRatsen_US
dc.subjectReishien_US
dc.subjectSkullen_US
dc.titleGanoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in ratsen_US
dc.titleGanoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats
dc.typeArticleen_US

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