Long term results of accelerated corneal collagen cross-linking in pediatric keratoconus

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dc.contributor.authorCinar, Yasin
dc.contributor.authorHan, Cagla Cilem
dc.contributor.authorSahin, Alparslan
dc.contributor.authorSyed, Zeba A.
dc.date.accessioned2024-04-24T17:14:42Z
dc.date.available2024-04-24T17:14:42Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To evaluate the long term visual, refractive, and corneal tomographic outcomes of epithelium-off accelerated corneal collagen cross-linking (ACXL) in the management of pediatric keratoconus (KC). Methods: This retrospective study included patients under 18 years old with progressive KC who underwent ACXL between 2012 and 2019 at Dicle University Hospital. Complete ophthalmic examination was performed including uncorrected distance visual acuity (UDVA), best spectacle-corrected distance visual acuity (CDVA), manifest refraction, and corneal tomography. Evaluations were performed preoperatively and at 6 months intervals postoperatively. Results: Forty-nine eyes of 49 patients were included in the study. The mean age of patients at the time of ACXL was 14.2 +/- 1.8 (range: 9.5-17.3) years. Mean follow up was 4.61 +/- 1.90 (range: 2.0-8.1) years. The mean LogMAR UDVA improved from 0.94 +/- 0.41 to 0.81 +/- 0.43, 0.69 +/- 0.41, and 0.67 +/- 0.33 after 1, 3, and 5 years respectively (p = 0.001). The mean LogMAR CDVA improved from 0.58 +/- 0.36 to 0.46 +/- 0.31, 0.34 +/- 0.23, and 0.39 +/- 0.27 after 1, 3, and 5 years respectively (p = 0.015). The mean refractive cylinder improved significantly from 6.01 +/- 2.07 diopters (D) to 5.46 +/- 1.87, 5.38 +/- 2.18, and 5.02 +/- 2.31 D after 1, 3, and 5 years respectively (p = 0.005). As compared to preoperative values, steep keratometry and maximum keratometry were not significantly different (p = 0.805 and 0.448, respectively) following ACXL, while flat keratometry significantly improved after ACXL (p = 0.012). Although central corneal thicknesses decreased significantly (p = 0.029), the decrease in thinnest corneal thickness was not statistically significant (p = 0.205). Conclusion: Epithelium-off ACXL seems to be effective for halting KC progression with long term clinical benefits in pediatric patients.en_US
dc.identifier.doi10.1177/11206721211018362
dc.identifier.endpage3499en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue6en_US
dc.identifier.pmid34015954
dc.identifier.scopus2-s2.0-85106423613
dc.identifier.scopusqualityQ2
dc.identifier.startpage3494en_US
dc.identifier.urihttps://doi.org/10.1177/11206721211018362
dc.identifier.urihttps://hdl.handle.net/11468/18145
dc.identifier.volume31en_US
dc.identifier.wosWOS:000679928500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneaen_US
dc.subjectCross-Linkingen_US
dc.subjectKeratoconusen_US
dc.subjectKeratoconus Progressionen_US
dc.titleLong term results of accelerated corneal collagen cross-linking in pediatric keratoconusen_US
dc.titleLong term results of accelerated corneal collagen cross-linking in pediatric keratoconus
dc.typeArticleen_US

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