Long term results of accelerated corneal collagen cross-linking in pediatric keratoconus
[ X ]
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To evaluate the long term visual, refractive, and corneal tomographic outcomes of epithelium-off accelerated corneal collagen cross-linking (ACXL) in the management of pediatric keratoconus (KC). Methods: This retrospective study included patients under 18 years old with progressive KC who underwent ACXL between 2012 and 2019 at Dicle University Hospital. Complete ophthalmic examination was performed including uncorrected distance visual acuity (UDVA), best spectacle-corrected distance visual acuity (CDVA), manifest refraction, and corneal tomography. Evaluations were performed preoperatively and at 6 months intervals postoperatively. Results: Forty-nine eyes of 49 patients were included in the study. The mean age of patients at the time of ACXL was 14.2 +/- 1.8 (range: 9.5-17.3) years. Mean follow up was 4.61 +/- 1.90 (range: 2.0-8.1) years. The mean LogMAR UDVA improved from 0.94 +/- 0.41 to 0.81 +/- 0.43, 0.69 +/- 0.41, and 0.67 +/- 0.33 after 1, 3, and 5 years respectively (p = 0.001). The mean LogMAR CDVA improved from 0.58 +/- 0.36 to 0.46 +/- 0.31, 0.34 +/- 0.23, and 0.39 +/- 0.27 after 1, 3, and 5 years respectively (p = 0.015). The mean refractive cylinder improved significantly from 6.01 +/- 2.07 diopters (D) to 5.46 +/- 1.87, 5.38 +/- 2.18, and 5.02 +/- 2.31 D after 1, 3, and 5 years respectively (p = 0.005). As compared to preoperative values, steep keratometry and maximum keratometry were not significantly different (p = 0.805 and 0.448, respectively) following ACXL, while flat keratometry significantly improved after ACXL (p = 0.012). Although central corneal thicknesses decreased significantly (p = 0.029), the decrease in thinnest corneal thickness was not statistically significant (p = 0.205). Conclusion: Epithelium-off ACXL seems to be effective for halting KC progression with long term clinical benefits in pediatric patients.
Açıklama
Anahtar Kelimeler
Cornea, Cross-Linking, Keratoconus, Keratoconus Progression
Kaynak
European Journal of Ophthalmology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
31
Sayı
6
