Characteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: Prospective multicenter observational 3K registry study

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dc.authorid0000-0003-2137-7934en_US
dc.contributor.authorAkarca, Ulus Salih
dc.contributor.authorÜnsal, Belkıs
dc.contributor.authorSezgin, Orhan
dc.contributor.authorYalçın, Kendal
dc.contributor.authorAkdoğan, Meral
dc.contributor.authorGönen, Can
dc.contributor.authorGündüz, Feyza
dc.contributor.authorÖzenirler, Seren
dc.contributor.authorSonsuz, Abdullah
dc.contributor.authorDinçer, Dinç
dc.contributor.authorTekin, Salim Başol
dc.contributor.authorYücel, İdris
dc.contributor.authorAkbulut, Hakan
dc.contributor.authorAlkım, Canan
dc.contributor.authorÖzyılkan, Özgür
dc.contributor.authorBaygül, Arzu
dc.contributor.authorÇevik, Zeynep Merve
dc.date.accessioned2021-12-30T11:46:08Z
dc.date.available2021-12-30T11:46:08Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionWOS:000727747700004
dc.descriptionPMID: 34876392
dc.description.abstractAims: To evaluate patient profile for epidemiological and clinicopathological characteristics and potential risk/prognostic factors in newly diagnosed hepatocellular carcinoma (HCC) patients across Turkey. Methods: A total of 547 patients (mean (SD) age 62.6 (10.3) years, 81.9% were males) were included in this registry study. Data on patient characteristics, etiologies of HCC, laboratory values, and tumor characteristics and stages were recorded at study enrollment. Results: HBV infection (68.2%) was the leading etiology, followed by HCV infection (17.2%), HDV infection (5.5%), alcohol (6.4%), and NAFLD (3.5%), as the major etiologies. Considering that 51.6% of the patients had >5 cm HCC, 44% were Child-Pugh B/C and 57% were BCLC B-D, it appears that a significant group of HCC patients were diagnosed at advanced stages. Of 540 patients, 271 (50.2%) were referred or applied with the diagnosis of HCC. Patients with HCC at presentation had larger tumor size (median (min-max) 6.6 (0-30) vs. 4.8 (0-90) cm, P<.001) and more advanced BCLC stage (Stage C-D in 40.8% vs. 26.4%, respectively, P=.005), compared to patients who were diagnosed during follow-up. Conclusions: Our findings revealed that HBV infection was the leading etiology and a moderate-to-advanced disease was evident in more than half of patients at the time of diagnosis. HCC patients diagnosed at follow-up had smaller tumor size and earlier BCLC stage.en_US
dc.identifier.citationAkarca, U.S., Ünsal, B., Sezgin, O., Yalçın, K., Akdoğan, M., Gönen, C. ve diğerleri. (2021). Characteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: Prospective multicenter observational 3K registry study. Turkish Journal of Gastroenterology, 32(12), 1019-1028.en_US
dc.identifier.doi10.5152/tjg.2021.201171
dc.identifier.endpage1028en_US
dc.identifier.issn2148-5607
dc.identifier.issue12en_US
dc.identifier.pmid34876392
dc.identifier.scopus2-s2.0-85122498900
dc.identifier.scopusqualityQ3
dc.identifier.startpage1019en_US
dc.identifier.trdizinid506348
dc.identifier.urihttps://hdl.handle.net/11468/8889
dc.identifier.volume32en_US
dc.identifier.wosWOS:000727747700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYalçın, Kendal
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectEpidemiologyen_US
dc.subjectRisk factorsen_US
dc.subjectPrognostic factorsen_US
dc.subjectScreeningen_US
dc.subjectTurkeyen_US
dc.titleCharacteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: Prospective multicenter observational 3K registry studyen_US
dc.titleCharacteristics of newly diagnosed hepatocellular carcinoma patients across Turkey: Prospective multicenter observational 3K registry study
dc.typeArticleen_US

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