Momordica charantia reduced ovarian ischemia - reperfusion injury by suppressing APAF-1 expression

Basit Öğe Kaydı
dc.authorid0000-0002-6384-9146en_US
dc.contributor.authorAşır, Fırat
dc.contributor.authorÖzgökçe, Çaǧdaş
dc.date.accessioned2023-10-05T12:50:26Z
dc.date.available2023-10-05T12:50:26Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: We investigate the effect of Momordica charantia (MC) against ovarian ischemia-reperfusion injury (IRI). MATERIALS AND METHODS: Forty-eight Sprague Dawley female rats were divided into 6 groups. 3 hours ischemia/3 hours reperfusion was conducted. Before and/or after IR, 600 mg/ kg MC were introduced to rats via an orogastric tube. At the end of the experiment, total serum antioxidant/oxidant status (TAS/TOS) and Anti-Mullerian Hormone (AMH) level were measured. Ovarian histopathology and APAF-1 expression level were analyzed. RESULTS: TAS and AMH levels were the lowest, while TOS level and OSI were the highest in the IR group. TAS and AMH levels were higher, and TOS levels and OSI were lower in MC-treated groups compared to IR group. Follicular degeneration, granulosa and stromal cell degeneration, mononuclear cell infiltration and vascular congestion and dilatation were observed in the IR group. Ovarian histopathology was improved in groups that received MC extract. APAF-1 immune activity was intense in IR and MC+IR groups while decreased in the groups treated with MC extract after IRI. MC treatment downregulated APAF-1 protein after IRI. CONCLUSIONS: MC extract restored negative biochemical and histochemical changes caused by IRI due to its antioxidant properties and supported cell survival by suppressing APAF-1 expression.en_US
dc.identifier.citationAşır, F. ve Özgökçe, Ç. (2023). Momordica charantia reduced ovarian ischemia - reperfusion injury by suppressing APAF-1 expression. European Review for Medical and Pharmacological Sciences, 27(6), 2182-2188.en_US
dc.identifier.doi10.26355/eurrev_202303_31751en_US
dc.identifier.endpage2188en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid37013735en_US
dc.identifier.scopus2-s2.0-85151652353en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2182en_US
dc.identifier.urihttps://www.europeanreview.org/article/31751
dc.identifier.urihttps://hdl.handle.net/11468/12753
dc.identifier.volume27en_US
dc.identifier.wosWOS:000971936600001
dc.identifier.wosWOS:000971936600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAşır, Fırat
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAPAF-1en_US
dc.subjectIschemiaen_US
dc.subjectMomordica charantiaen_US
dc.subjectOvaryen_US
dc.subjectReperfusionen_US
dc.titleMomordica charantia reduced ovarian ischemia - reperfusion injury by suppressing APAF-1 expressionen_US
dc.typeArticleen_US

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