The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study

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dc.authorid0000-0002-1967-4844en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorLaçin, Nihat
dc.contributor.authorİzol, Bozan Serhat
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorDeveci, Buşra
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2021-11-03T07:21:41Z
dc.date.available2021-11-03T07:21:41Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.descriptionPMID:31066788
dc.description.abstractPurpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats. Methods: Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days. Results: Histopathological examination revealed inflammation in control group (defect group), congestion in blood vessels, and an increase in osteoclast cells. In defect + graft group, osteoclastic activity was observed and osteocyte cells were continued to develop. In defect + graft + simvastatin group, osteocytes and matrix formation were increased in the new bone trabeculae. Osteopontin and osteonectin expression were positive in the osteclast cells in the control group. Osteoblasts and some osteocytes showed a positive reaction of osteopontin and osteopontin. In defect + graft + simvastatin group, osteonectin and osteopontin expression were positive in osteoblast and osteocyte cells, and a positive expression in osteon formation was also seen in new bone trabeculae. Conclusion: The simvastatin application was thought to increase bone turnover by increasing the osteoinductive effect with graft and significantly affect the formation of new bone.en_US
dc.identifier.citationLaçin, N., İzol, B. S., Özkorkmaz, E. G., Deveci, B. ve Tuncer, C. M. (2019). The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study. Acta Cirurgica Brasileira, 34(4), e201900408.en_US
dc.identifier.doi10.1590/s0102-865020190040000008
dc.identifier.issn0102-8650
dc.identifier.issue4en_US
dc.identifier.pmid31066788
dc.identifier.scopus2-s2.0-85065800551
dc.identifier.scopusqualityQ2
dc.identifier.startpagee201900408en_US
dc.identifier.urihttps://www.scielo.br/j/acb/a/CBPKmsgbLvMVX3Hqpv6bYqt/?lang=en
dc.identifier.urihttps://hdl.handle.net/11468/8096
dc.identifier.volume34en_US
dc.identifier.wosWOS:000467739400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkorkmaz, Ebru Gökalp
dc.institutionauthorDeveci, Buşra
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteogenesisen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectRatsen_US
dc.subjectSimvastatinen_US
dc.titleThe effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical studyen_US
dc.titleThe effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study
dc.typeArticleen_US

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