Molecular identification of HIV-1 in the presence of hepatitis B Virus and hepatitis C virus co-infections

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dc.contributor.authorSayan, Murat
dc.contributor.authorÖzgüler, Müge
dc.contributor.authorYıldırım, Figen Sarıgül
dc.contributor.authorYıldırmak, Taner
dc.contributor.authorGündüz, Alper
dc.contributor.authorDokuzoğuz, Başak
dc.contributor.authorÇelen, Mustafa Kemal
dc.contributor.authorİnan, Dilara
dc.contributor.authorHeper, Yasemin
dc.contributor.authorErsöz, Gülden
dc.contributor.authorKaraoğlan, İlkay
dc.contributor.authorCeran, Nurgül
dc.contributor.authorDeveci, Aydın
dc.contributor.authorÖztürk, Servet
dc.contributor.authorKutlu, Selda Sayın
dc.contributor.authorÖzdemir, Hülya Özkan
dc.contributor.authorAkbulut, Ayhan
dc.contributor.authorYazıcı, Saadet
dc.contributor.authorŞener, Alper
dc.contributor.authorÇağatay, Atahan
dc.contributor.authorÜnal, Serhat
dc.date.accessioned2021-09-10T13:24:16Z
dc.date.available2021-09-10T13:24:16Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000526082100003
dc.descriptionPMID: 32106666
dc.description.abstractBackground: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency vim were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Antihuman immunodeficiency virus positive patients with HBsAg andior anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-I infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative.en_US
dc.identifier.citationSayan, M., Özgüler, M., Yıldırım, F.S., Yıldırmak, T., Gündüz, A., Dokuzoğuz, B. ve diğerleri. Molecular identification of HIV-1 in the presence of hepatitis B Virus and hepatitis C virus co-infections. Balkan Medical Journal, 37(3), 125-130.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2020.2019.5.89en_US
dc.identifier.endpage130en_US
dc.identifier.issn2146-3123
dc.identifier.issue3en_US
dc.identifier.pmid32106666en_US
dc.identifier.scopus2-s2.0-85083621463en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage125en_US
dc.identifier.trdizinidhttps://search.trdizin.gov.tr/yayin/detay/373725en_US
dc.identifier.urihttps://balkanmedicaljournal.org/en/molecular-identification-of-hiv-1-in-the-presence-of-hepatitis-b-virus-and-hepatitis-c-virus-co-infections-133675
dc.identifier.uri2146-3131
dc.identifier.urihttps://hdl.handle.net/11468/7516
dc.identifier.volume37en_US
dc.identifier.wosWOS:000526082100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÇelen, Mustafa Kemal
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCo-infectionen_US
dc.subjectHepatitis B virusen_US
dc.subjectHepatitis C virusen_US
dc.subjectHIV-1en_US
dc.subjectMolecular epidemiologyen_US
dc.titleMolecular identification of HIV-1 in the presence of hepatitis B Virus and hepatitis C virus co-infectionsen_US
dc.typeArticleen_US

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