Comparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controls

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dc.authoridSubasi Turgut, Fatma/0000-0002-9971-8375
dc.contributor.authorKaradag, Mehmet
dc.contributor.authorTurgut, Fatma Subasi
dc.contributor.authorCiftci, Zehra
dc.contributor.authorHangul, Zehra
dc.contributor.authorTaysi, Seyithan
dc.date.accessioned2025-02-22T14:08:43Z
dc.date.available2025-02-22T14:08:43Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function. This study aimed to compare USP9X and TGF-(3 levels in children with autism and healthy controls, and explore their relationship with autism severity. Methods: Serum USP9X and TGF-(3 levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism. Results: Our study revealed a significant increase in USP9X levels (p=0.001) among children with autism compared to controls. However, TGF-(3 levels showed no significant difference between the two groups. Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-(3. Conclusions: This study is the first to compare serum USP9X levels in children with autism to healthy controls. Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.en_US
dc.identifier.doi10.29399/npa.28650
dc.identifier.endpage312en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue4en_US
dc.identifier.pmid39678057en_US
dc.identifier.scopus2-s2.0-85212044178en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.29399/npa.28650
dc.identifier.urihttps://hdl.handle.net/11468/29591
dc.identifier.volume61en_US
dc.identifier.wosWOS:001378159700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegien_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectAutismen_US
dc.subjectUSP9Xen_US
dc.subjectTGF-betaen_US
dc.subjectEtiologyen_US
dc.titleComparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controlsen_US
dc.typeArticleen_US

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