Comparison of Serum USP9x and TGF-β Levels in Children with Autism Spectrum Disorders with Healthy Controls
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function. This study aimed to compare USP9X and TGF-(3 levels in children with autism and healthy controls, and explore their relationship with autism severity. Methods: Serum USP9X and TGF-(3 levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism. Results: Our study revealed a significant increase in USP9X levels (p=0.001) among children with autism compared to controls. However, TGF-(3 levels showed no significant difference between the two groups. Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-(3. Conclusions: This study is the first to compare serum USP9X levels in children with autism to healthy controls. Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.
Açıklama
Anahtar Kelimeler
Autism, USP9X, TGF-beta, Etiology
Kaynak
Noropsikiyatri Arsivi-Archives of Neuropsychiatry
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
61
Sayı
4
