Gallic acid treatment protects intestinal tissue against ischaemia-reperfusion

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorDurgun, Cemalettin
dc.contributor.authorDeveci, Engin
dc.date.accessioned2023-11-03T08:11:53Z
dc.date.available2023-11-03T08:11:53Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: This study aimed to investigate the protective effects of gallic acid (GA) in the rat intestine against ischaemia-reperfusion (IR) injury. Materials and methods: Thirty male Wistar albino rats with a mean weight of 200–250 g were used. Animals were categorized into the sham, IR, and IR+GA groups. Ischaemia of the intestine was induced for 3 h by occluding the superior mesenteric artery (SMA) and then left for 3 h of reperfusion. In the IR+GA group, after ischaemia induction, 50 mg/kg GA was orally administered to the animals. Blood samples were collected for biochemical assays. Intestinal tissues were excised for histopathologic and immunohistochemical processing. Results: Malondialdehyde (MDA) levels were increased, and catalase (CAT) and glutathione (GSH) levels were decreased in the IR group compared to the sham group. After GA treatment, MDA levels decreased and CAT and GSH levels increased in the GA-treated group compared to the IR group. In the sham group, normal intestinal histology was observed. In the IR group, the villi structures were completely degenerated. In the IR+GA group, histology was improved after GA treatment. In the sham group, the caspase-3 reaction was generally negative in the epithelium and glands. In the IR group, the caspase-3 reaction increased in apoptotic bodies and inflammatory cells. The caspase-3 reaction was negative in goblet cells and the epithelium. A moderate caspase-3 reaction was observed in the IR+GA group. The beclin-1 reaction was negative in epithelial cells and goblet cells in villi in the sham group. In the IR group, the beclin-1 reaction was positive in the degenerated villi. An intense beclin-1 reaction was also observed in some inflammatory cells. After GA treatment, the beclin-1 reaction was positive in a few cells. In general, moderate beclin-1 positivity was observed. Conclusions: Gallic acid, with its antioxidative effect, inhibited the apoptotic pathway (caspase-3) through beclin-1 regulation. (Folia Morphol 2023; 82, 3: 633–640)en_US
dc.identifier.citationDurgun, C. ve Deveci, E. (2023). Gallic acid treatment protects intestinal tissue against ischaemia-reperfusion. Folia morphologica, 82(3), 633-640.en_US
dc.identifier.doi10.5603/FM.a2023.0034
dc.identifier.endpage640en_US
dc.identifier.issn1644-3284
dc.identifier.issue3en_US
dc.identifier.pmid37183516
dc.identifier.scopus2-s2.0-85169292124
dc.identifier.scopusqualityQ2
dc.identifier.startpage633en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/FM.a2023.0034/71552
dc.identifier.urihttps://hdl.handle.net/11468/13041
dc.identifier.volume82en_US
dc.identifier.wosWOS:001064109200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofFolia morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschaemia-reperfusionen_US
dc.subjectGallic aciden_US
dc.subjectCaspase-3en_US
dc.subjectBeclin-1en_US
dc.titleGallic acid treatment protects intestinal tissue against ischaemia-reperfusionen_US
dc.titleGallic acid treatment protects intestinal tissue against ischaemia-reperfusion
dc.typeArticleen_US

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