Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study

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dc.contributor.authorArslan, Serkan
dc.contributor.authorZeytun, Hikmet
dc.contributor.authorBasuguy, Erol
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorUygun, Ibrahim
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorTan, Ilhan
dc.date.accessioned2024-04-24T17:27:46Z
dc.date.available2024-04-24T17:27:46Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of the present study was to investigate whether cordycepin prevented adhesion formation in a rat model. METHODS: Rats were randomly assigned to 3 groups of 10 rats. Control group: The absence of adhesion was confirmed via laparotomy. Adhesion group: The cecum was removed from the abdomen and scraped with a dry gauze bandage until petechial hemorrhagic foci developed. Cordycepin group: The same surgical procedure was performed as in the adhesion group, and 10 mg/kg cordycepin was administered intraperitoneally. After 15 days, the rats were sacrificed humanely via cardiac blood withdrawal under anesthesia. The rats were then analyzed morphologically and histopathologically, and hydroxyproline (OH-p) and malondialdehyde (MDA) levels were measured. RESULTS: Macroscopic analysis revealed significantly less adhesion in the cordycepin group than in the adhesion group (p<0.01). Furthermore, significant histopathological improvement was also evident in the cordycepin group compared to the adhesion group (p<0.05). The levels of OH-p and MDA in blood and tissue were higher in the adhesion group than in the control group, and lower in the cordycepin group than the adhesion group. Interestingly, MDA level was significantly lower (blood: p<0.05; tissue: p<0.01) in the cordycepin group than in the adhesion group, whereas only tissue OH-p was significantly lower in the cordycepin group compared with the adhesion group (p<0.05). One rat in both adhesion group and cordycepin group died postoperatively. CONCLUSION: Results indicated that cordycepin effectively reduced adhesion in a rat abrasion model. Thus, this agent may be valuable to prevent postoperative adhesion.en_US
dc.description.sponsorshipScientific Research and Project Coordinator (DUBAP) of Dicle University [I4-TF-44]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research and Project Coordinator (DUBAP, I4-TF-44) of Dicle University.en_US
dc.identifier.doi10.5505/tjtes.2016.48979
dc.identifier.endpage278en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid28762461
dc.identifier.scopus2-s2.0-85025468040
dc.identifier.scopusqualityQ3
dc.identifier.startpage273en_US
dc.identifier.trdizinid263400
dc.identifier.urihttps://doi.org/10.5505/tjtes.2016.48979
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/263400
dc.identifier.urihttps://hdl.handle.net/11468/20188
dc.identifier.volume23en_US
dc.identifier.wosWOS:000407527600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbdominalen_US
dc.subjectAdhesionen_US
dc.subjectCordycepinen_US
dc.subjectExperimentalen_US
dc.subjectRaten_US
dc.subjectStudyen_US
dc.titleCordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental studyen_US
dc.titleCordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study
dc.typeArticleen_US

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