Epithelial–mesenchymal transition in acute leukemias
Yükleniyor...
Dosyalar
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Epithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for the differentiation of many tissues and organs. EMT can also be induced in advanced-stage cancers, leading to further malignant behavior and chemotherapy resistance, resulting in an unfavorable prognosis for patients. Although EMT was long considered and studied only in solid tumors, it has been shown to be involved in the pathogenesis of hematological malignancies, including acute leukemias. Indeed, there is increasing evidence that EMT promotes the progression of acute leukemias, leading to the emergence of a more aggressive phenotype of the disease, and also causes chemotherapy resistance. The current literature suggests that the levels and activities of EMT inducers and markers can be used to predict prognosis, and that targeting EMT in addition to conventional therapies may increase treatment success in acute leukemias.
Açıklama
Anahtar Kelimeler
EMT, Leukemia, Neoplasia, Cell adhesion, Signaling
Kaynak
International Journal of Molecular Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
25
Sayı
4
Künye
Varışli, L. ve Vlahopoulos, S. (2024). Epithelial–mesenchymal transition in acute leukemias. International Journal of Molecular Sciences, 25(4), 2173
