Epithelial–mesenchymal transition in acute leukemias

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dc.authorid0000-0002-4337-9327en_US
dc.contributor.authorVarışli, Lokman
dc.contributor.authorVlahopoulos, Spiros
dc.date.accessioned2024-02-16T12:25:55Z
dc.date.available2024-02-16T12:25:55Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractEpithelial–mesenchymal transition (EMT) is a metabolic process that confers phenotypic flexibility to cells and the ability to adapt to new functions. This transition is critical during embryogenesis and is required for the differentiation of many tissues and organs. EMT can also be induced in advanced-stage cancers, leading to further malignant behavior and chemotherapy resistance, resulting in an unfavorable prognosis for patients. Although EMT was long considered and studied only in solid tumors, it has been shown to be involved in the pathogenesis of hematological malignancies, including acute leukemias. Indeed, there is increasing evidence that EMT promotes the progression of acute leukemias, leading to the emergence of a more aggressive phenotype of the disease, and also causes chemotherapy resistance. The current literature suggests that the levels and activities of EMT inducers and markers can be used to predict prognosis, and that targeting EMT in addition to conventional therapies may increase treatment success in acute leukemias.en_US
dc.identifier.citationVarışli, L. ve Vlahopoulos, S. (2024). Epithelial–mesenchymal transition in acute leukemias. International Journal of Molecular Sciences, 25(4), 2173en_US
dc.identifier.doi10.3390/ijms25042173
dc.identifier.endpage20en_US
dc.identifier.issue4en_US
dc.identifier.pmid38396852
dc.identifier.scopus2-s2.0-85185916367
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/1422-0067/25/4/2173
dc.identifier.urihttps://hdl.handle.net/11468/13350
dc.identifier.volume25en_US
dc.identifier.wosWOS:001172132600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVarışli, Lokman
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEMTen_US
dc.subjectLeukemiaen_US
dc.subjectNeoplasiaen_US
dc.subjectCell adhesionen_US
dc.subjectSignalingen_US
dc.titleEpithelial–mesenchymal transition in acute leukemiasen_US
dc.titleEpithelial–mesenchymal transition in acute leukemias
dc.typeArticleen_US

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