Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains

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dc.authorid0000-0001-9654-1319en_US
dc.authorid0000-0003-2489-3619en_US
dc.authorid0000-0002-7085-623Xen_US
dc.authorid0000-0003-1211-9677en_US
dc.contributor.authorBektaş, Hava
dc.contributor.authorAlgül, Şermin
dc.contributor.authorAltındağ, Fikret
dc.contributor.authorYeğin, Korkut
dc.contributor.authorAkdağ, Mehmet Zülküf
dc.contributor.authorDaşdağ, Süleyman
dc.date.accessioned2024-03-19T13:06:42Z
dc.date.available2024-03-19T13:06:42Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractDiabetes, mobile phone use, and obesity have increased simultaneously in recent years. The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the heads of users. With 5 G, which has started to be used in some countries without the necessary precautions being taken, the amount of RFR to which living things are exposed will increase. In this study, the changes in energy homeostasis and redox balance caused by 5 G (3.5 GHz, GSM-modulated) were explored. The effects of RFR on the brains of diabetic and healthy rats were investigated and histopathological analysis was performed. Twenty-eight Wistar albino rats weighing 200–250 g were divided into 4 groups as sham, RFR, diabetes, and RFR+diabetes groups (n = 7). The rats in each group were kept in a plexiglass carousel for 2 h a day for 30 days. While the rats in the experimental groups were exposed to RFR for 2 h a day, the rats in the sham group were kept under the same experimental conditions but with the radiofrequency generator turned off. At the end of the experiment, brain tissues were collected from euthanized rats. Total antioxidant (TAS), total oxidant (TOS), hydrogen peroxide (H2O2), ghrelin, nesfatin-1, and irisin levels were determined. In addition, histopathological analyses of the brain tissues were performed. The specific absorption rate in the gray matter of the brain was calculated as 323 mW/kg and 195 mW/kg for 1 g and 10 g averaging, respectively. After RFR exposure among diabetic and healthy rats, decreased TAS levels and increased TOS and H2O2 levels were observed in brain tissues. RFR caused increases in ghrelin and irisin and a decrease in nesfatin-1 in the brain. It was also observed that RFR increased the number of degenerated neurons in the hippocampus. Our results indicate that 3.5 GHz RFR causes changes in the energy metabolism and appetite of both healthy and diabetic rats. Thus, 5 G may not be innocent in terms of its biological effects, especially in the presence of diabetes.en_US
dc.identifier.citationBektaş, H., Algül, Ş., Altındağ, F., Yeğin, K., Akdağ, M. Z. ve Daşdağ, S. (2022). Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains. Journal of Chemical Neuroanatomy, 126,1-10.en_US
dc.identifier.doi10.1016/j.jchemneu.2022.102168
dc.identifier.endpage10en_US
dc.identifier.issn0891-0618
dc.identifier.pmid36220504
dc.identifier.scopus2-s2.0-85140093810
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0891061822000989?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13645
dc.identifier.volume126en_US
dc.identifier.wosWOS:000877424300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkdağ, Mehmet Zülküf
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Chemical Neuroanatomy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectDiabetesen_US
dc.subjectGhrelinen_US
dc.subjectIrisinen_US
dc.subjectNesfatin-1en_US
dc.subjectRadiofrequency radiationen_US
dc.titleEffects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brainsen_US
dc.titleEffects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains
dc.typeArticleen_US

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