Vitamin D deficiency prevalence in late neonatal hypocalcemia: A multicenter study

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dc.authorid0000-0003-0903-6520en_US
dc.contributor.authorSeymen-Karabulut, Gülcan
dc.contributor.authorGünlemez, Ayla
dc.contributor.authorGökalp, Ayşe Sevim
dc.contributor.authorHatun, Şükrü
dc.contributor.authorNarter, Fatma Kaya
dc.contributor.authorMutlu, Mehmet
dc.contributor.authorErtuğrul, Sabahattin
dc.date.accessioned2023-01-20T11:36:28Z
dc.date.available2023-01-20T11:36:28Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns. Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels. Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients. Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.en_US
dc.identifier.citationSeymen-Karabulut, G., Günlemez, A., Gökalp, A.S., Hatun, S., Narter, F.K., Mutlu, M. ve diğerleri. (2021). Vitamin D deficiency prevalence in late neonatal hypocalcemia: A multicenter study. Journal of Clinical Research in Pediatric Endocrinology, 13(4), 384-390.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2020.2021.0169
dc.identifier.endpage390en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue4en_US
dc.identifier.pmid34013710
dc.identifier.scopus2-s2.0-85122224644
dc.identifier.scopusqualityQ2
dc.identifier.startpage384en_US
dc.identifier.trdizinid521131
dc.identifier.urihttps://cms.galenos.com.tr/Uploads/Article_47423/JCRPE-13-384-En.pdf
dc.identifier.urihttps://hdl.handle.net/11468/11211
dc.identifier.volume13en_US
dc.identifier.wosWOS:000734457400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErtuğrul, Sabahattin
dc.language.isoenen_US
dc.publisherGalenos Yayıncılıken_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin D deficiencyen_US
dc.subjectHypocalcemiaen_US
dc.subjectInfanten_US
dc.subjectNewbornen_US
dc.titleVitamin D deficiency prevalence in late neonatal hypocalcemia: A multicenter studyen_US
dc.titleVitamin D deficiency prevalence in late neonatal hypocalcemia: A multicenter study
dc.typeArticleen_US

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