Asporin levels in patients with temporomandibular joint disorders

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dc.authorid0000-0002-1279-0893en_US
dc.authorid0000-0002-8726-3182en_US
dc.authorid0000-0003-1817-1230en_US
dc.authorid0000-0002-2456-7381en_US
dc.contributor.authorEge, Bilal
dc.contributor.authorErdoğmuş, Zozan
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorKoparal, Mahmut
dc.contributor.authorKurt, Muhammed Yusuf
dc.contributor.authorGülsün, Belgin
dc.date.accessioned2024-03-28T07:35:32Z
dc.date.available2024-03-28T07:35:32Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız-Diş-Çene Hastalıkları ve Cerrahisi Bölümüen_US
dc.description.abstractBackground: Understanding the pathogenesis of temporomandibular joint disorder (TMD) is important for diagnosis and treatment planning. Thus, biochemical analysis is usually used for the detection of tissue damage. Objective: In this study, we aimed to investigate the serum asporin levels in patients with TMD. Methods: Our study was planned to be performed on 43 healthy individuals (control group) without any joint problems and 43 patients with temporomandibular joint internal derangement (TMJ-ID; patients group) according to the Wilkes classification (stages 3, 4 and 5). Serum asporin levels were determined by the enzyme-linked immunosorbent assay (ELISA) method and compared between groups. Asporin levels were analysed according to the demographic and clinical characteristics of the patients, and the differences between them were demonstrated. Results: Asporin levels were found to be significantly increased in the patients group compared to control group (p =.0303). The age and gender distributions of the samples in the control and patients groups were homogeneous, and there was no statistically significant difference between the groups. In addition, while there was no significant change in asporin levels in females in the patients group compared with the control group, the asporin levels were significantly increased in males in the patients group (p =.0403). Conclusions: Consequently, asporin seems to be an important biomarker in the pathobiology of TMJ-ID as it is significantly upregulated in these patients.en_US
dc.identifier.citationEge, B., Erdoğmuş, Z., Bozgeyik, E., Koparal, M., Kurt, M. Y. ve Gülsün, B. (2021). Asporin levels in patients with temporomandibular joint disorders. Journal of Oral Rehabilitation, 48(10), 1109-1117.en_US
dc.identifier.doi10.1111/joor.13234
dc.identifier.endpage1117en_US
dc.identifier.issn0305-182X
dc.identifier.issue10en_US
dc.identifier.pmid34309889
dc.identifier.scopus2-s2.0-85114138116
dc.identifier.scopusqualityQ1
dc.identifier.startpage1109en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/joor.13234
dc.identifier.urihttps://hdl.handle.net/11468/13760
dc.identifier.volume48en_US
dc.identifier.wosWOS:000693777300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGülsün, Belgin
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Oral Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsporinen_US
dc.subjectBiochemical analysisen_US
dc.subjectInternal derangementen_US
dc.subjectTemporomandibular joint disordersen_US
dc.subjectWilkes classificationen_US
dc.titleAsporin levels in patients with temporomandibular joint disordersen_US
dc.titleAsporin levels in patients with temporomandibular joint disorders
dc.typeArticleen_US

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