The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer

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dc.contributor.authorAday, Ulaş
dc.contributor.authorBöyük, Abdullah
dc.contributor.authorAkkoç, Hasan
dc.date.accessioned2021-06-29T11:58:00Z
dc.date.available2021-06-29T11:58:00Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionWOS:000567477200005
dc.descriptionPMID: 32908848
dc.description.abstractPurpose: The purpose of our study was initially to explore the prognostic role of LDH-to-albumin ratio in patients with colorectal carcinoma (CRC) undergoing curative resection. Methods: The retrospective study included 295 CRC patients that underwent curative resection. According to time-dependent receiver operating characteristics (ROC) analysis, the optimal cutoff value for pretreatment LDH-to-albumin ratio was 52.7. Cox regression univariate and multivariate analyses were utilized to analyze the prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: The 295 participants included 117 women (39.7%) and had an overall mean age of 55.8 ± 14.1 years. The median follow-up period was 31.8 ± 21 months (range, 6-78 months) and 53 patients (18.0%) died from cancer during the followup period. The 5-year DFS and OS rates were 65.4% and 68.5% in patients with LDH-to-albumin ratio <52.7 (n = 152), and were 55.2% and 55.4% in patients with LDH-to-albumin ratio ≥52.7 (n = 143), respectively. Kaplan-Meier curves showed that LDH-to-albumin ratio ≥52.7 was significantly associated with worse DFS and OS (P = 0.003 and P < 0.001, respectively). Multivariate analyses revealed that LDH-to-albumin ratio was an independent predictor of resectable CRC (odds ratio, 2.104; 95% confidence interval, 1.112-3.982; P = 0.022). Conclusion: Our study revealed that high pretreatment LDH-to-albumin ratio level was an unfavorable prognosticator in patients with CRC undergoing curative resection. LDH-to-albumin ratio is a candidate to be a prognostic biomarker in clinical practice. © 2020 Korean Surgical Society. All rights reserved.en_US
dc.identifier.citationAday, U., Böyük, A. ve Akkoç, H. (2020). The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer. Annals of Surgical Treatment and Research, 99(3), 161-170.en_US
dc.identifier.doi10.4174/astr.2020.99.3.161
dc.identifier.endpage170en_US
dc.identifier.issn2288-6575
dc.identifier.issn2288-6796
dc.identifier.issue3en_US
dc.identifier.pmid32908848
dc.identifier.scopus2-s2.0-85093679753
dc.identifier.scopusqualityQ2
dc.identifier.startpage161en_US
dc.identifier.urihttps://astr.or.kr/DOIx.php?id=10.4174/astr.2020.99.3.161
dc.identifier.urihttps://hdl.handle.net/11468/7161
dc.identifier.volume99en_US
dc.identifier.wosWOS:000567477200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAday, Ulaş
dc.language.isotren_US
dc.publisherKorean Surgical Societyen_US
dc.relation.ispartofAnnals of Surgical Treatment and Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorectal neoplasmsen_US
dc.subjectLactate dehydrogenase-to-albumin ratioen_US
dc.subjectSurvivalen_US
dc.titleThe prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal canceren_US
dc.titleThe prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer
dc.typeArticleen_US

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