The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Surgical Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: The purpose of our study was initially to explore the prognostic role of LDH-to-albumin ratio in patients with colorectal carcinoma (CRC) undergoing curative resection. Methods: The retrospective study included 295 CRC patients that underwent curative resection. According to time-dependent receiver operating characteristics (ROC) analysis, the optimal cutoff value for pretreatment LDH-to-albumin ratio was 52.7. Cox regression univariate and multivariate analyses were utilized to analyze the prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: The 295 participants included 117 women (39.7%) and had an overall mean age of 55.8 ± 14.1 years. The median follow-up period was 31.8 ± 21 months (range, 6-78 months) and 53 patients (18.0%) died from cancer during the followup period. The 5-year DFS and OS rates were 65.4% and 68.5% in patients with LDH-to-albumin ratio <52.7 (n = 152), and were 55.2% and 55.4% in patients with LDH-to-albumin ratio ≥52.7 (n = 143), respectively. Kaplan-Meier curves showed that LDH-to-albumin ratio ≥52.7 was significantly associated with worse DFS and OS (P = 0.003 and P < 0.001, respectively). Multivariate analyses revealed that LDH-to-albumin ratio was an independent predictor of resectable CRC (odds ratio, 2.104; 95% confidence interval, 1.112-3.982; P = 0.022). Conclusion: Our study revealed that high pretreatment LDH-to-albumin ratio level was an unfavorable prognosticator in patients with CRC undergoing curative resection. LDH-to-albumin ratio is a candidate to be a prognostic biomarker in clinical practice. © 2020 Korean Surgical Society. All rights reserved.
Açıklama
WOS:000567477200005
PMID: 32908848
PMID: 32908848
Anahtar Kelimeler
Colorectal neoplasms, Lactate dehydrogenase-to-albumin ratio, Survival
Kaynak
Annals of Surgical Treatment and Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
99
Sayı
3
Künye
Aday, U., Böyük, A. ve Akkoç, H. (2020). The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer. Annals of Surgical Treatment and Research, 99(3), 161-170.
