Histopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area

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dc.authorid0002-7794-1744en_US
dc.authorid0000-0001-7317-5467en_US
dc.contributor.authorYılmaz, Utku Nezih
dc.contributor.authorUysal, Rojdan Ferman Güneş
dc.contributor.authorYilmaz, Berivan Dündar
dc.contributor.authorTuncer, Cudi Mehmet
dc.date.accessioned2021-09-27T11:05:33Z
dc.date.available2021-09-27T11:05:33Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız-Diş-Çene Hastalıkları ve Cerrahisi Bölümüen_US
dc.descriptionPMID:31063202
dc.description.abstractBackground: An abscess is a pocket of pus that forms around the root of an infected tooth. In this study, we aimed to investigate the extracellular matrix proteases ADAMTS1, ADAMTS4, osteonectin, and osteopontin expressions in abscess fluid cells in jaws after implantation and prosthesis operation. Materials and methods: In this clinical study, abscess fluids belonging to 17 patients who applied to the Department of Oral and Maxillofacial Surgery were examined histopathologically and immunohistochemically. In the histopathological examination of the abscess fluid, separation of chromatin bridges in the nuclei of neutrophil cells, pyknosis and apoptotic changes in the nucleus, degenerative change in the cytoplasm, and occasional vacuolar structures were observed. Results: The positive reaction of ADAMTS1 was observed in fibroblast cells, plasma cells, and macrophage cells. The positive reaction of ADAMTS4 was observed in fibroblast cells, osteoclast cells, and some apoptotic leukocyte cells. Osteopontin expression in osteoclastic cells and polymorphonuclear cells was defined as positive. Osteonectin expression was positive in polymorphonuclear leukocytes and hypertrophic fibroblast cells. Conclusions: ADAMTS1 and ADAMTS4 may induce bone destruction with its distinctive property in alveolar bone resorption, which promotes the activation of osteoclasts, which can accelerate the destruction of the extracellular matrix in the acute phase. Furthermore, osteoclastic activity increased with the increase of osteonectin and osteopontin protein expression due to inflammation in the abscess cases.en_US
dc.identifier.citationYılmaz, U. N., Uysal, R. F. G., Yilmaz, B. D. ve Tuncer, C. M. (2019). Histopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area. Folia Morphologica (Poland), 78(4), 754-761.en_US
dc.identifier.doi10.5603/FM.a2019.0051
dc.identifier.endpage761en_US
dc.identifier.issn0015-5659
dc.identifier.issue4en_US
dc.identifier.pmid31063202
dc.identifier.scopus2-s2.0-85077613998
dc.identifier.scopusqualityQ2
dc.identifier.startpage754en_US
dc.identifier.urihttps://journals.viamedica.pl/folia_morphologica/article/view/63619
dc.identifier.urihttps://hdl.handle.net/11468/7785
dc.identifier.volume78en_US
dc.identifier.wosWOS:000510490300012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Utku Nezih
dc.institutionauthorUysal, Rojdan Ferman Güneş
dc.institutionauthorYilmaz, Berivan Dündar
dc.institutionauthorTuncer, Cudi Mehmet
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofFolia Morphologica (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectADAMTS1en_US
dc.subjectADAMTS4en_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectTooth abscessen_US
dc.titleHistopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial areaen_US
dc.titleHistopathologic and immunohistochemical investigations of dental abscess formed in maxillofacial area
dc.typeArticleen_US

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