Paraoxonase and arylesterase activity in bladder cancer

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dc.contributor.authorUtangac, Mehmet Mazhar
dc.contributor.authorYeni, Ercan
dc.contributor.authorSavas, Murat
dc.contributor.authorAltunkol, Adem
dc.contributor.authorCiftci, Halil
dc.contributor.authorGumus, Kemal
dc.contributor.authorDemir, Mehmet
dc.date.accessioned2024-04-24T17:27:32Z
dc.date.available2024-04-24T17:27:32Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes. Material and methods: The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enzyme activity and tumour grade, stage, muscular invasion and tumour size were evaluated. For statistical analysis, One-Sample Kolmogorov-Smirnov, Independent-T, ANOVA and Post-Hoc Bonferroni tests were used. Results: Serum levels of PON1 and ARE enzymes, and total cholesterol were significantly lower in bladder cancer group. While other lipid parameters were similar in both the patient and the control groups. Levels of ARE were positively correlated with lipid parameters except for HDL cholesterol. Conclusion: Our results showed that decreased serum PON1 and ARE enzyme activities are related with tumour load and recurrence. Further studies with larger samples are needed to confirm predictive role of enzymatic activities of PON1 and ARE in the diagnosis and prognosis of bladder cancer.en_US
dc.identifier.doi10.5152/tud.2017.89411
dc.identifier.endpage151en_US
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.issue2en_US
dc.identifier.pmid28717537
dc.identifier.scopus2-s2.0-85020215633
dc.identifier.scopusqualityQ3
dc.identifier.startpage147en_US
dc.identifier.trdizinid290603
dc.identifier.urihttps://doi.org/10.5152/tud.2017.89411
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/290603
dc.identifier.urihttps://hdl.handle.net/11468/20028
dc.identifier.volume43en_US
dc.identifier.wosWOS:000402553200008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectArylesteraseen_US
dc.subjectBladder Canceren_US
dc.subjectParaoxonaseen_US
dc.titleParaoxonase and arylesterase activity in bladder canceren_US
dc.titleParaoxonase and arylesterase activity in bladder cancer
dc.typeArticleen_US

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