Do oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?

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dc.authorid0000-0003-0544-4906en_US
dc.authorid0000-0002-2677-3971en_US
dc.contributor.authorÜzel, Ali
dc.contributor.authorEbik, Berat
dc.contributor.authorBucaktepe, Gamze Erten
dc.contributor.authorYolaçan, Ramazan
dc.contributor.authorKarabulut, Ümit
dc.contributor.authorUçmak, Feyzullah
dc.date.accessioned2024-03-25T10:15:28Z
dc.date.available2024-03-25T10:15:28Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractObjective The effect of antiviral drugs on the erectile dysfunction (ED) problem expressed by some patients using antiviral drugs due to chronic hepatitis B infection (HBV) was investigated. Methods A total of 102 male patients receiving antiviral therapy for HBVinfection without any known non-cirrhotic and comorbid disease that may cause ED and whodon't use any drugs with an ED formation potential were analyzed through the InternationalIndex of Erectile Function test. Results Among the patients admitted to the study, anxiety disorder was detected as 24.5% (n = 25) and depression as 46.1% (n = 47). 70.6% (n = 72) of the patients suffered ED. Severe ED was only detected in 3 (n = 2.9%) patients. ED was detected in 70.6% of the entecavir, 64.2% of tenofovir, and 80% of Tenofovir alafenamide users (P = 0.287). On the other hand, the logistics regression analysis revealed that the most important factors that increase the risk of ED are age (>55 age; RR: 2.66; P < 0.001), and anxiety disorder (RR: 2.30; P < 0.0001). The cumulative effect of antiviral drugs on ED was 5.7% (RR: 0.8; P = 0.156). Conclusion We could not find any mounting evidence relating to the effect ofcommonly used antiviral drugs for hepatitis B causing ED. The incidence rate of ED on ourpatients was at a similar rate with population studies in the literature based on society. It is notappropriate to terminate antiviral therapy in hepatitis B for this reason.en_US
dc.identifier.citationÜzel, A., Ebik, B., Bucaktepe, G. E., Yolaçan, R., Karabulut, Ü. ve Uçmak, F. (2024). Do oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?. European Journal of Gastroenterology and Hepatology, 36(2), 184-189.en_US
dc.identifier.doi10.1097/MEG.0000000000002672
dc.identifier.endpage189en_US
dc.identifier.issn0954-691X
dc.identifier.issue2en_US
dc.identifier.pmid37942730
dc.identifier.scopus2-s2.0-85180607812
dc.identifier.scopusqualityQ2
dc.identifier.startpage184en_US
dc.identifier.urihttps://journals.lww.com/eurojgh/fulltext/2024/02000/do_oral_antiviral_drugs_used_in_the_treatment_of.6.aspx
dc.identifier.urihttps://hdl.handle.net/11468/13697
dc.identifier.volume36en_US
dc.identifier.wosWOS:001130449200005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBucaktepe, Gamze Erten
dc.institutionauthorKarabulut, Ümit
dc.institutionauthorUçmak, Feyzullah
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology and Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiviral drugsen_US
dc.subjectChronic hepatitis Ben_US
dc.subjectErectile dysfunctionen_US
dc.titleDo oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?en_US
dc.titleDo oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?
dc.typeArticleen_US

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