Do oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams and Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective The effect of antiviral drugs on the erectile dysfunction (ED) problem expressed by some patients using antiviral drugs due to chronic hepatitis B infection (HBV) was investigated. Methods A total of 102 male patients receiving antiviral therapy for HBVinfection without any known non-cirrhotic and comorbid disease that may cause ED and whodon't use any drugs with an ED formation potential were analyzed through the InternationalIndex of Erectile Function test. Results Among the patients admitted to the study, anxiety disorder was detected as 24.5% (n = 25) and depression as 46.1% (n = 47). 70.6% (n = 72) of the patients suffered ED. Severe ED was only detected in 3 (n = 2.9%) patients. ED was detected in 70.6% of the entecavir, 64.2% of tenofovir, and 80% of Tenofovir alafenamide users (P = 0.287). On the other hand, the logistics regression analysis revealed that the most important factors that increase the risk of ED are age (>55 age; RR: 2.66; P < 0.001), and anxiety disorder (RR: 2.30; P < 0.0001). The cumulative effect of antiviral drugs on ED was 5.7% (RR: 0.8; P = 0.156). Conclusion We could not find any mounting evidence relating to the effect ofcommonly used antiviral drugs for hepatitis B causing ED. The incidence rate of ED on ourpatients was at a similar rate with population studies in the literature based on society. It is notappropriate to terminate antiviral therapy in hepatitis B for this reason.
Açıklama
Anahtar Kelimeler
Antiviral drugs, Chronic hepatitis B, Erectile dysfunction
Kaynak
European Journal of Gastroenterology and Hepatology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
36
Sayı
2
Künye
Üzel, A., Ebik, B., Bucaktepe, G. E., Yolaçan, R., Karabulut, Ü. ve Uçmak, F. (2024). Do oral antiviral drugs used in the treatment of chronic hepatitis B cause erectile dysfunction?. European Journal of Gastroenterology and Hepatology, 36(2), 184-189.
