Evaluation of optimal gastric mucosal biopsy site and number for identification of Helicobacter pylori, gastric atrophy and intestinal metaplasia
[ X ]
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
H G E Update Medical Publishing S A
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Aims: The study is designed to identify the optimal gastric mucosal biopsy site and number for identification of Helicobacter pylori, gastric atrophy and intestinal metaplasia. Methodology: Ninety-two patients were included in the study, gastric biopsies were obtained from 5 different sites: lesser curvature of the mid-antrum (A(1)), greater curvature of the mid-antrum (A(2)), incisura angularis (IA), lesser curvature of the mid-corpus (B-1), greater curvature of the mid-corpus (B-2). Helicobacter pylori was evaluated in sections stained with toluidine blue, and histopathological. examination was performed in sections stained with hematoxylineosin. Results: Seventy-three patients were positive for Helicobacter pylori at least in one biopsy site. Helicobacter pylori was positive in 47 patients (64.3%) in A(1), in 54 patients (73.9%) in A(2), in 60 patients (82.1%) in IA, 44 patients (60.2%) in B-1, and in 42 patients (57.5%) in B-2. The highest positivity determined was in the combination of A(2) and IA sites (95.8%). Gastric atrophy was determined in 35 of 73 patients (27.1% in A(1), 20% in A(2),25.7% in IA, 20% in B-1, and 7% in B-2). Intestinal metaplasia was determined in B-1 of the Helicobacter pylori-positive patients (18% in A(1), 16% in A(2), 30.9% in IA, 21.8% in B-1, 12.7% in B-2). Conclusions: It is considered that taking biopsies from both A(1) and IA sites has the highest sensitivity in detecting Helicobacter pylori. However, it is difficult to define a specific site for detecting gastric atrophy and intestinal metaplasia.
Açıklama
Anahtar Kelimeler
Helicobacter Pylori, Atrophy, Intestinal Metaplasia
Kaynak
Hepato-Gastroenterology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
51
Sayı
60
