Vitamin D can be used as a supplement against cancer stem cells

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dc.authorid165258en_US
dc.authorid190240en_US
dc.authorid181573en_US
dc.authorid0000-0002-1727-1582en_US
dc.authorid0000-0001-6979-3713en_US
dc.authorid0000-0001-5518-5004en_US
dc.contributor.authorKoçak, Nadir
dc.contributor.authorNergiz, Süleyman
dc.contributor.authorYıldırım, İbrahim Halil
dc.contributor.authorDuran, Yağmur
dc.date.accessioned2020-04-16T18:13:19Z
dc.date.available2020-04-16T18:13:19Z
dc.date.issued2018
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü, Veterinerlik Genetiği Anabilim Dalıen_US
dc.description.abstractCancer is standing like a bottomless pit or a black hole in front of mankind. Scientists are trying all possible ways to find a solution against to cancer. As known, cancer is a phenomenon fed from internal dynamics. One of internal dynamic is cancer stem cells that are involved in the formation and development of cancer. Because of these dynamics, scientists began to search solution inside of the body. Another internal dynamic is vitamin D and it is not only important in calcium homeostasis but also it is important for cell proliferation, differentiation, and apoptosis. In this study, we investigated the effect of vitamin D on cancer stem cells that sorted from MCF-7 cell line and on HEK293 cell line as control. Our results showed that calcitriol treatment reduced the number of CSC (Cancer Stem Cell) in the MCF-7 cell while increased in HEK293 cell population. Gene expression analyses showed that effect of calcitriol on apoptosis plays an important role in this reduction. Deficiency or unavailability of vitamin D may take a role in the pathogenesis of breast cancer.en_US
dc.identifier.citationKoçak, N., Nergiz, S., Yıldırım, İ.H., ve Duran, Y. (2018). Vitamin D can be used as a supplement against cancer stem cells. Cellular and Molecular Biology, 64(12), 47-51.en_US
dc.identifier.doi10.14715/cmb/2018.64.12.10
dc.identifier.endpage51en_US
dc.identifier.issn1165-158X
dc.identifier.issn0145-5680
dc.identifier.issue12en_US
dc.identifier.pmid30301502
dc.identifier.scopus2-s2.0-85054779708
dc.identifier.scopusqualityQ4
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/11468/5286
dc.identifier.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/1903
dc.identifier.volume64en_US
dc.identifier.wosWOS:000449068700010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherCMB Association Publishersen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcitriolen_US
dc.subjectVitamin Den_US
dc.subjectCancer stem cellen_US
dc.subjectMCF-7en_US
dc.subjectHEK293en_US
dc.titleVitamin D can be used as a supplement against cancer stem cellsen_US
dc.titleVitamin D can be used as a supplement against cancer stem cells
dc.typeArticleen_US

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